Endothelial cell protein C receptor (EPCR) levels in tissue from control rats and from rats given lipopolysaccharide B from E coli O127:B8 (LPS) or thrombin
| Tissue . | Control (n = 5) . | LPS (n = 5) . | Thrombin (n = 2) . |
|---|---|---|---|
| Lung | 904.1 ± 284.5 | 675.2 ± 255.4 | 984.7 ± 263.1 |
| Heart | 1324.7 ± 278.1 | 1593.6 ± 645.2 | 1290.6 ± 312.9 |
| Tissue . | Control (n = 5) . | LPS (n = 5) . | Thrombin (n = 2) . |
|---|---|---|---|
| Lung | 904.1 ± 284.5 | 675.2 ± 255.4 | 984.7 ± 263.1 |
| Heart | 1324.7 ± 278.1 | 1593.6 ± 645.2 | 1290.6 ± 312.9 |
Rats were either injected with endotoxin (50 mg/kg) or infused with thrombin (5 U/kg per hour for 3 hours). Six hours after endotoxin injection and 3 hours after thrombin infusion, they were perfused transcardially and lung and heart tissue were extracted with use of Triton X-100. EPCR antigen in the tissues was measured by an enzyme-linked immunosorbent assay. In controls, the results are expressed as the mean ± SE. In rats given LPS or the thrombin infusion, the results are expressed as the mean ± SD.
EPCR levels are given in mg/g.