Plasma factor VIII levels determined in normal and von Willebrand factor-knockout mice with the 2-stage and chromogenic assays using a human standard plasma as reference
| Strain . | n . | FVIII Assay Mean U/mL ± SD (CV%) . | |
|---|---|---|---|
| 2-Stage . | Chromogenic . | ||
| NMRI | |||
| Male + female | 53 | 0.49 ± 0.39 (80%) | 1.03 ± 0.64 (62%) |
| Male | 33 | 0.57 ± 0.43 (75%) | 1.17 ± 0.75 (64%) |
| Female | 20 | 0.37 ± 0.27 (73%) | 0.80 ± 0.30 (38%) |
| C57B1/6J | |||
| Male + female | 20 | 0.28 ± 0.17 (61%) | 0.66 ± 0.39 (59%) |
| Male | 9 | 0.37 ± 0.19 (51%) | 0.80 ± 0.51 (64%) |
| Female | 11 | 0.20 ± 0.12 (57%) | 0.55 ± 0.21 (39%) |
| Balb/c | |||
| Male + female | 14 | 0.29 ± 0.19 (66%) | 1.60 ± 0.85 (53%) |
| Male | 8 | 0.34 ± 0.25 (72%) | 2.25 ± 0.26 (12%) |
| Female | 6 | 0.23 ± 0.05 (23%) | 0.74 ± 0.47 (63%) |
| vWD | |||
| Male + female | 4 | 0.07 ± 0.03 (40%) | 0.02 ± 0.01 (44%) |
| Male | 2 | 0.06 ± 0.02 (40%) | 0.02 ± 0.00 (16%) |
| Female | 2 | 0.09 ± 0.03 (34%) | 0.03 ± 0.01 (46%) |
| Strain . | n . | FVIII Assay Mean U/mL ± SD (CV%) . | |
|---|---|---|---|
| 2-Stage . | Chromogenic . | ||
| NMRI | |||
| Male + female | 53 | 0.49 ± 0.39 (80%) | 1.03 ± 0.64 (62%) |
| Male | 33 | 0.57 ± 0.43 (75%) | 1.17 ± 0.75 (64%) |
| Female | 20 | 0.37 ± 0.27 (73%) | 0.80 ± 0.30 (38%) |
| C57B1/6J | |||
| Male + female | 20 | 0.28 ± 0.17 (61%) | 0.66 ± 0.39 (59%) |
| Male | 9 | 0.37 ± 0.19 (51%) | 0.80 ± 0.51 (64%) |
| Female | 11 | 0.20 ± 0.12 (57%) | 0.55 ± 0.21 (39%) |
| Balb/c | |||
| Male + female | 14 | 0.29 ± 0.19 (66%) | 1.60 ± 0.85 (53%) |
| Male | 8 | 0.34 ± 0.25 (72%) | 2.25 ± 0.26 (12%) |
| Female | 6 | 0.23 ± 0.05 (23%) | 0.74 ± 0.47 (63%) |
| vWD | |||
| Male + female | 4 | 0.07 ± 0.03 (40%) | 0.02 ± 0.01 (44%) |
| Male | 2 | 0.06 ± 0.02 (40%) | 0.02 ± 0.00 (16%) |
| Female | 2 | 0.09 ± 0.03 (34%) | 0.03 ± 0.01 (46%) |
CV% = coefficient of variation.