Effect of receptor-associated protein on plasma factor VIII levels in von Willebrand factor knockout mice
| Measurement (hrs after injection) . | n . | FVIII Levels (U/mL) . | |||
|---|---|---|---|---|---|
| 2-Stage Assay . | Chromogenic Assay . | ||||
| Mean ± SD (CV%) . | P . | Mean ± SD (CV%) . | P . | ||
| Male + female | |||||
| 0 | 10 | 0.05 ± 0.02 (34%) | 0.06 ± 0.03 (53%) | ||
| 0.5 | 8 | 0.10 ± 0.02 (25%) | .0002 | 0.11 ± 0.03 (30%) | .0013 |
| 1 | 8 | 0.09 ± 0.04 (44%) | .0108 | 0.10 ± 0.06 (61%) | .0421 |
| 3 | 2 | 0.07 ± 0.004 (6%) | .0052 | 0.11 ± 0.01 (11%) | .0060 |
| Male | |||||
| 0 | 5 | 0.04 ± 0.02 (51%) | 0.06 ± 0.04 (60%) | ||
| 0.5 | 4 | 0.11 ± 0.03 (24%) | .0043 | 0.11 ± 0.04 (40%) | .0742 |
| 1 | 5 | 0.10 ± 0.04 (40%) | .0144 | 0.11 ± 0.06 (53%) | .0867 |
| 3 | — | nd | nd | nd | nd |
| Female | |||||
| 0 | 5 | 0.05 ± 0.01 (14%) | 0.05 ± 0.02 (33%) | ||
| 0.5 | 4 | 0.08 ± 0.01 (17%) | .0052 | 0.11 ± 0.02 (20%) | .0024 |
| 1 | 3 | 0.06 ± 0.01 (14%) | .0702 | 0.08 ± 0.07 (88%) | .2450 |
| 3 | 2 | 0.07 ± 0.004 (6%) | .0118 | 0.11 ± 0.01 (11%) | .0091 |
| Measurement (hrs after injection) . | n . | FVIII Levels (U/mL) . | |||
|---|---|---|---|---|---|
| 2-Stage Assay . | Chromogenic Assay . | ||||
| Mean ± SD (CV%) . | P . | Mean ± SD (CV%) . | P . | ||
| Male + female | |||||
| 0 | 10 | 0.05 ± 0.02 (34%) | 0.06 ± 0.03 (53%) | ||
| 0.5 | 8 | 0.10 ± 0.02 (25%) | .0002 | 0.11 ± 0.03 (30%) | .0013 |
| 1 | 8 | 0.09 ± 0.04 (44%) | .0108 | 0.10 ± 0.06 (61%) | .0421 |
| 3 | 2 | 0.07 ± 0.004 (6%) | .0052 | 0.11 ± 0.01 (11%) | .0060 |
| Male | |||||
| 0 | 5 | 0.04 ± 0.02 (51%) | 0.06 ± 0.04 (60%) | ||
| 0.5 | 4 | 0.11 ± 0.03 (24%) | .0043 | 0.11 ± 0.04 (40%) | .0742 |
| 1 | 5 | 0.10 ± 0.04 (40%) | .0144 | 0.11 ± 0.06 (53%) | .0867 |
| 3 | — | nd | nd | nd | nd |
| Female | |||||
| 0 | 5 | 0.05 ± 0.01 (14%) | 0.05 ± 0.02 (33%) | ||
| 0.5 | 4 | 0.08 ± 0.01 (17%) | .0052 | 0.11 ± 0.02 (20%) | .0024 |
| 1 | 3 | 0.06 ± 0.01 (14%) | .0702 | 0.08 ± 0.07 (88%) | .2450 |
| 3 | 2 | 0.07 ± 0.004 (6%) | .0118 | 0.11 ± 0.01 (11%) | .0091 |
CV% = coefficient of variation; nd = not determined.
P calculated for comparison to time point 0.