Inhibition of HIV-1 replication by... | American Society of Hematology

Inhibition of HIV-1 replication by alloantigen-stimulated supernatants derived from PBMC cultures of healthy blood bank donors and HIV-1– infected individuals

Donors	Inhibition^*		Cytokine Content (pg/mL)
Donors	HIV-1_BZ167	HIV-1_Ba-L	IL-2	IFN-γ	IL-10	IFN-α	RANTES
Control	6/12 (0-86%)	4/9 (0-91%)	87 ± 25	172 ± 72	27 ± 11	<20	1125 ± 669
HIV⁺ ^1-153	5/13 (0-87%)	6/12 (0-89%)	27 ± 15	96 ± 30	12 ± 4	<20	1025 ± 333

Donors	Inhibition^*		Cytokine Content (pg/mL)
Donors	HIV-1_BZ167	HIV-1_Ba-L	IL-2	IFN-γ	IL-10	IFN-α	RANTES
Control	6/12 (0-86%)	4/9 (0-91%)	87 ± 25	172 ± 72	27 ± 11	<20	1125 ± 669
HIV⁺ ^1-153	5/13 (0-87%)	6/12 (0-89%)	27 ± 15	96 ± 30	12 ± 4	<20	1025 ± 333

Fraction of individuals with supernatants that inhibited HIV-1 replication greater than 50% (range of inhibition of viral replication).

F1-153

Median CD4 T-cell counts = 662 cells/μL (range, 195-787).

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