Adverse effects of amifostine by dose groups
Symptom . | Group . | Grade (% Patients) . | |
---|---|---|---|
Grade 1 . | Grade 2 . | ||
Nausea | 1 | 3.6 | 0 |
2 | 14 | 3.6 | |
3 | 11 | 3.6 | |
Vomiting | 1 | 3.6 | 0 |
2 | 7 | 7 | |
3 | 3.6 | 7 | |
Decreased appetite | 1 | 0 | 0 |
2 | 0 | 3.6 | |
3 | 3.6 | 0 | |
Hypotension | 1 | 0 | 0 |
2 | 0 | 7 | |
3 | 0 | 7 | |
Rash | 1 | 0 | 0 |
2 | 3.6 | 3.6 | |
3 | 0 | 3.6 | |
Fever | 1 | 0 | 0 |
2 | 0 | 7.1 | |
3 | 0 | 0 | |
Depression | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 | |
Anxiety | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 3.6 |
Symptom . | Group . | Grade (% Patients) . | |
---|---|---|---|
Grade 1 . | Grade 2 . | ||
Nausea | 1 | 3.6 | 0 |
2 | 14 | 3.6 | |
3 | 11 | 3.6 | |
Vomiting | 1 | 3.6 | 0 |
2 | 7 | 7 | |
3 | 3.6 | 7 | |
Decreased appetite | 1 | 0 | 0 |
2 | 0 | 3.6 | |
3 | 3.6 | 0 | |
Hypotension | 1 | 0 | 0 |
2 | 0 | 7 | |
3 | 0 | 7 | |
Rash | 1 | 0 | 0 |
2 | 3.6 | 3.6 | |
3 | 0 | 3.6 | |
Fever | 1 | 0 | 0 |
2 | 0 | 7.1 | |
3 | 0 | 0 | |
Depression | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 0 | |
Anxiety | 1 | 0 | 0 |
2 | 0 | 0 | |
3 | 0 | 3.6 |
Group 1, amifostine 200 mg/M2 intravenously 3 times a week; group 2, amifostine 300 mg/M2 intravenously 3 times a week; group 3, amifostine 400 mg/M2 intravenously 3 times a week.