Central nervous system studies after transplantation for sickle cell disease
| Patient No. . | Indication for BMT . | Baseline Cerebral MRI . | 1 y post-BMT . | 2 y post-BMT . | ≥ 3 y post-BMT . |
|---|---|---|---|---|---|
| 1 | Stroke | Watershed infarct L MCA | Stable | Stable | |
| 2 | Stroke | Infarct and stenosis of bilat MCAs | Stable | — | Stable |
| 3 | Stroke | R MCA infarct; stenotic R ICA/MCA | — | — | Stable |
| 5 | ACS, TIAs | Normal | — | — | Normal |
| 6 | ACS & abnl MRI | Foci of increased T2 signal in bilat centrum semiovale | Stable | Stable | |
| 7 | Stroke | Multiple small deep white matter infarcts | — | Stable | |
| 8 | ACS | Normal | — | — | Stable |
| 10 | VOC | Normal | — | — | Normal |
| 11 | VOC/stroke | Abnormal | — | — | Improved |
| 12 | ACS | — | Normal | ||
| 13 | Stroke | Multiple periventricular and R frontal foci of increased T2 signal | Stable | ||
| 14 | Stroke | R MCA infarct with moya, L ICA stenosis | — | Stable | |
| 15 | Stroke | Abnormal | Stable | Stable | |
| 16 | VOC | Normal | — | Stable | Stable |
| 17 | Stroke | R parietal, occipital infarct, occluded MCAs, bilat | — | Stable | |
| 18 | ACS, abnl MRI | Lukomalacia | New R frontal-parietal infarct | — | Stable/stable |
| 19 | Stroke | Bilat ICA stenosis, multiple infarcts, ↑T2 signal in L centrum semiovale & frontal white matter | New stroke after GR | ||
| 20 | Stroke | Encephalomalacia, L watershed infarcts | Stable | ||
| 21 | VOC | — | — | ||
| 22 | VOC | — | — | ||
| 23 | Stroke | L frontal infarction | — | Stable | Stable |
| 24 | ACS | Normal | Stable | Stable | |
| 25 | VOC | — | — | ||
| 26 | ACS, abnl MRI | Foci of ↑ signal in centrum semiovale, bilaterally | Stable | Stable | |
| 27 | ACS, abnl MRI | L frontal & L parietal watershed infarcts. L ICA occlusion. R ICA mild to severe stenosis | — | ||
| 28 | Stroke | Infarction & occluded L ICA | Stable | Stable |
| Patient No. . | Indication for BMT . | Baseline Cerebral MRI . | 1 y post-BMT . | 2 y post-BMT . | ≥ 3 y post-BMT . |
|---|---|---|---|---|---|
| 1 | Stroke | Watershed infarct L MCA | Stable | Stable | |
| 2 | Stroke | Infarct and stenosis of bilat MCAs | Stable | — | Stable |
| 3 | Stroke | R MCA infarct; stenotic R ICA/MCA | — | — | Stable |
| 5 | ACS, TIAs | Normal | — | — | Normal |
| 6 | ACS & abnl MRI | Foci of increased T2 signal in bilat centrum semiovale | Stable | Stable | |
| 7 | Stroke | Multiple small deep white matter infarcts | — | Stable | |
| 8 | ACS | Normal | — | — | Stable |
| 10 | VOC | Normal | — | — | Normal |
| 11 | VOC/stroke | Abnormal | — | — | Improved |
| 12 | ACS | — | Normal | ||
| 13 | Stroke | Multiple periventricular and R frontal foci of increased T2 signal | Stable | ||
| 14 | Stroke | R MCA infarct with moya, L ICA stenosis | — | Stable | |
| 15 | Stroke | Abnormal | Stable | Stable | |
| 16 | VOC | Normal | — | Stable | Stable |
| 17 | Stroke | R parietal, occipital infarct, occluded MCAs, bilat | — | Stable | |
| 18 | ACS, abnl MRI | Lukomalacia | New R frontal-parietal infarct | — | Stable/stable |
| 19 | Stroke | Bilat ICA stenosis, multiple infarcts, ↑T2 signal in L centrum semiovale & frontal white matter | New stroke after GR | ||
| 20 | Stroke | Encephalomalacia, L watershed infarcts | Stable | ||
| 21 | VOC | — | — | ||
| 22 | VOC | — | — | ||
| 23 | Stroke | L frontal infarction | — | Stable | Stable |
| 24 | ACS | Normal | Stable | Stable | |
| 25 | VOC | — | — | ||
| 26 | ACS, abnl MRI | Foci of ↑ signal in centrum semiovale, bilaterally | Stable | Stable | |
| 27 | ACS, abnl MRI | L frontal & L parietal watershed infarcts. L ICA occlusion. R ICA mild to severe stenosis | — | ||
| 28 | Stroke | Infarction & occluded L ICA | Stable | Stable |
Abnl = abnormal; ACS = acute chest syndrome; bilat = bilateral; BMT = bone marrow transplantation; GR = graft rejection; ICA = internal carotid artery; L = left; MCA = middle carotid artery; MRI = magnetic resonance imaging; R = right; TCD = transcranial Doppler; TIA = transient ischemic attack; VOC = vaso-occlusive crisis.