Patient characteristics
| . | Cyclin D1-positive (n = 128) . | Cyclin D1-negative (n = 23) . | P . |
|---|---|---|---|
| Age (y), median (range) | 65 (36–81) | 60 (31–74) | .04 |
| Age >60 | 81 (63%) | 11 (48%) | |
| Sex (M/F) | 89/39 | 15/8 | .68 |
| Stage | |||
| I | 6 (5%) | 4 (17%) | |
| II | 13 (10%) | 3 (13%) | .46 |
| III | 32 (26%) | 3 (13%) | |
| IV | 74 (59%) | 13 (56%) | |
| Extranodal involvement | 87 (71%) | 17 (74%) | .80 |
| ≥2 sites | 43 (36%) | 8 (35%) | .88 |
| BM and/or PB | 61 (50%) | 12 (52%) | .82 |
| Spleen | 45 (36%) | 6 (26%) | .37 |
| Liver | 19 (15%) | 4 (17%) | .80 |
| GI tract | 34 (27%) | 2 (9%) | .05 |
| Waldeyer ring | 13 (10%) | 2 (9%) | .59 |
| Orbit | 3 (2%) | 3 (13%) | .05 |
| Serum LDH > normal | 38 (33%) | 4 (18%) | .14 |
| PS ≥2 | 24 (21%) | 2 (9%) | .16 |
| International prognostic index | |||
| Low | 28 (23%) | 9 (39%) | |
| Low-intermediate | 39 (32%) | 9 (39%) | .04 |
| High-intermediate | 31 (25%) | 4 (17%) | |
| High | 19 (15%) | 1 (4%) |
| . | Cyclin D1-positive (n = 128) . | Cyclin D1-negative (n = 23) . | P . |
|---|---|---|---|
| Age (y), median (range) | 65 (36–81) | 60 (31–74) | .04 |
| Age >60 | 81 (63%) | 11 (48%) | |
| Sex (M/F) | 89/39 | 15/8 | .68 |
| Stage | |||
| I | 6 (5%) | 4 (17%) | |
| II | 13 (10%) | 3 (13%) | .46 |
| III | 32 (26%) | 3 (13%) | |
| IV | 74 (59%) | 13 (56%) | |
| Extranodal involvement | 87 (71%) | 17 (74%) | .80 |
| ≥2 sites | 43 (36%) | 8 (35%) | .88 |
| BM and/or PB | 61 (50%) | 12 (52%) | .82 |
| Spleen | 45 (36%) | 6 (26%) | .37 |
| Liver | 19 (15%) | 4 (17%) | .80 |
| GI tract | 34 (27%) | 2 (9%) | .05 |
| Waldeyer ring | 13 (10%) | 2 (9%) | .59 |
| Orbit | 3 (2%) | 3 (13%) | .05 |
| Serum LDH > normal | 38 (33%) | 4 (18%) | .14 |
| PS ≥2 | 24 (21%) | 2 (9%) | .16 |
| International prognostic index | |||
| Low | 28 (23%) | 9 (39%) | |
| Low-intermediate | 39 (32%) | 9 (39%) | .04 |
| High-intermediate | 31 (25%) | 4 (17%) | |
| High | 19 (15%) | 1 (4%) |
BM, bone marrow; PB, peripheral blood; GI, gastrointestinal; PS, performance status.