Histologic features of cyclin D1-positive and -negative patients
| . | Cyclin D1-positive (n = 128) Number (%) . | Cyclin D1-negative (n = 23) Number (%) . | P . |
|---|---|---|---|
| Morphology | |||
| Growth pattern | |||
| Typical mantle zone pattern | 22 (17) | 6 (26) | |
| Vaguly nodular | 48 (38) | 7 (30) | .57 |
| Diffuse | 58 (45) | 10 (43) | |
| Cell size | |||
| Small | 3 (2) | 2 (9) | |
| Intermediate | 59 (46) | 16 (70) | |
| Medium | 44 (34) | 5 (22) | .006 |
| Medium to large | 17 (13) | 0 | |
| Large | 5 (4) | 0 | |
| Morphologic variants | |||
| Blastic/blastoid | 11 (9) | 0 | .15 |
| Pleomorphic | 10 (8) | 0 | .18 |
| Residual follicular pattern | |||
| Naked germinal centers | 45 (35) | 11 (48) | .25 |
| Mitotic index | |||
| High (>25/20HPF) | 42 (33) | 1 (4) | .003 |
| Low (<24/20HPF) | 86 (67) | 22 (96) |
| . | Cyclin D1-positive (n = 128) Number (%) . | Cyclin D1-negative (n = 23) Number (%) . | P . |
|---|---|---|---|
| Morphology | |||
| Growth pattern | |||
| Typical mantle zone pattern | 22 (17) | 6 (26) | |
| Vaguly nodular | 48 (38) | 7 (30) | .57 |
| Diffuse | 58 (45) | 10 (43) | |
| Cell size | |||
| Small | 3 (2) | 2 (9) | |
| Intermediate | 59 (46) | 16 (70) | |
| Medium | 44 (34) | 5 (22) | .006 |
| Medium to large | 17 (13) | 0 | |
| Large | 5 (4) | 0 | |
| Morphologic variants | |||
| Blastic/blastoid | 11 (9) | 0 | .15 |
| Pleomorphic | 10 (8) | 0 | .18 |
| Residual follicular pattern | |||
| Naked germinal centers | 45 (35) | 11 (48) | .25 |
| Mitotic index | |||
| High (>25/20HPF) | 42 (33) | 1 (4) | .003 |
| Low (<24/20HPF) | 86 (67) | 22 (96) |
HPF, high-power field.