Response to deferoxamine (DFO) therapy of patients who did not receive blood transfusions during treatment
| Patient No. . | Diagnosis . | Age, y/Sex . | Initial Ferritin Level (μg/L) . | TIL before Chelation (mg/kg)* . | UIE after DFO Bolus (μg/48 h) . | UIE after DFO Infusion (μg/48 h) . | Follow-up Time (mo) . | Last Ferritin Value (μg/L)† . |
|---|---|---|---|---|---|---|---|---|
| 11 | RCA | 69/F | 2600 | 267.7 | 13 885 | 11 940 | 18 | 1210 |
| 13 | MDS, RA | 55/M | 1022 | 74.0 | 7836 | 8842 | 18 | 63 |
| 16 | AML, CR | 61/F | 2214 | 135.9 | 2325 | 2625 | 24 | 452 |
| 18 | ALL, CR | 57/M | 1557 | 137.8 | 3600 | 4200 | 14 | 490 |
| 20 | S/H | 45/M | 2360 | — | 6200 | 5780 | 28 | 740 |
| 21 | AML, CR | 36/M | 1625 | 112.8 | 5470 | 6660 | 21 | 250 |
| 23 | AML, CR | 35/M | 1460 | 123.2 | 4580 | 4970 | 18 | 440 |
| 24 | ALL, CR | 18/M | 980 | 94.2 | 2240 | 2470 | 12 | 230 |
| 25 | ALL, CR | 22/M | 1170 | 101.5 | 4600 | 4760 | 20 | 210 |
| 26 | ALL, CR | 47/M | 1320 | 118.1 | 3800 | 3460 | 22 | 240 |
| 27 | MM | 57/F | 1570 | 108.7 | 4430 | 4170 | 16 | 690 |
| 1625.3 ± 543.3 | 127.4 ± 52.9 | 5360.5 ± 3256.6 | 5443.4 ± 2827.1 | 18.3 ± 3.9 | 455.9 ± 325.6 |
| Patient No. . | Diagnosis . | Age, y/Sex . | Initial Ferritin Level (μg/L) . | TIL before Chelation (mg/kg)* . | UIE after DFO Bolus (μg/48 h) . | UIE after DFO Infusion (μg/48 h) . | Follow-up Time (mo) . | Last Ferritin Value (μg/L)† . |
|---|---|---|---|---|---|---|---|---|
| 11 | RCA | 69/F | 2600 | 267.7 | 13 885 | 11 940 | 18 | 1210 |
| 13 | MDS, RA | 55/M | 1022 | 74.0 | 7836 | 8842 | 18 | 63 |
| 16 | AML, CR | 61/F | 2214 | 135.9 | 2325 | 2625 | 24 | 452 |
| 18 | ALL, CR | 57/M | 1557 | 137.8 | 3600 | 4200 | 14 | 490 |
| 20 | S/H | 45/M | 2360 | — | 6200 | 5780 | 28 | 740 |
| 21 | AML, CR | 36/M | 1625 | 112.8 | 5470 | 6660 | 21 | 250 |
| 23 | AML, CR | 35/M | 1460 | 123.2 | 4580 | 4970 | 18 | 440 |
| 24 | ALL, CR | 18/M | 980 | 94.2 | 2240 | 2470 | 12 | 230 |
| 25 | ALL, CR | 22/M | 1170 | 101.5 | 4600 | 4760 | 20 | 210 |
| 26 | ALL, CR | 47/M | 1320 | 118.1 | 3800 | 3460 | 22 | 240 |
| 27 | MM | 57/F | 1570 | 108.7 | 4430 | 4170 | 16 | 690 |
| 1625.3 ± 543.3 | 127.4 ± 52.9 | 5360.5 ± 3256.6 | 5443.4 ± 2827.1 | 18.3 ± 3.9 | 455.9 ± 325.6 |
TIL indicates total iron load; UIE, urinary iron excretion; RCA, red cell aplasia; MDS, myelodysplastic syndrome; RA, refractory anemia; AML, acute myeloid leukemia; CR, complete remission; ALL, acute lymphoblastic leukemia; S/H, spherocytosis and hemochromatosis; and MM, multiple myeloma. Plus-minus values are mean ± SD.
TIL before chelation therapy is expressed as the total amount of iron transfused per kilogram of body weight; TIL during chelation therapy was not measured in these patients because they did not receive transfusions during DFO therapy.
Normal range of serum ferritin concentration, 15-250 μg/L.