Plasma levels and specific activities of transgenic mouse-derived factor VIII relative to normal human factor VIII
| Transgenic line no. | 6 | 10 | 31 |
| Plasma factor VIII antigen level (ng/mL) | 233 | 128 | 255 |
| Plasma factor VIII antigen level relative to human factor VIII | 0.83 | 0.46 | 0.91 |
| Specific activity relative to human factor VIII | 0.61 | 0.42 | 1.00 |
| n = 3 | n = 3 | n = 4 |
| Transgenic line no. | 6 | 10 | 31 |
| Plasma factor VIII antigen level (ng/mL) | 233 | 128 | 255 |
| Plasma factor VIII antigen level relative to human factor VIII | 0.83 | 0.46 | 0.91 |
| Specific activity relative to human factor VIII | 0.61 | 0.42 | 1.00 |
| n = 3 | n = 3 | n = 4 |
Plasma levels of factor VIII antigen were assayed by ELISA specific for human factor VIII. The level of factor VIII in pooled human plasma samples approximated 280 ng/mL. Specific activity was calculated by dividing factor VIII activity (measured using the COAMATIC assay) by the plasma level of factor VIII. Relative specific activity was determined by the ratio of specific activity for transgenic factor VIII to specific activity for normal human factor VIII. Results represent averages for each line based on the number (n) of mice assayed.