Diagnostic criteria and histologic subgroups
| Category . | Diagnostic criteria . | Histologic subtype . |
|---|---|---|
| Group 1 Lymphomatoid papulosis (n = 118) | ▸ Recurrent, self-healing papulonodular eruption. ▸ Note: spontaneous complete remission of every individual skin lesion, irrespective of the appearance of new lesions. ▸ Histologic features suggesting (CD30+) CTCL. | LyP, type A: (n = 93) LyP, type B: (n = 6) LyP, type C: (n = 8) LyP, mixed (A, B, or both): (n = 11) |
| Group 2 Primary cutaneous CD30+ large T-cell lymphoma (n = 79) | ▸ Most (>75%) or large clusters of neoplastic cells express the CD30 antigen and have a T- or null cell phenotype ▸ No clinical evidence of LyP ▸ No prior or concurrent LyP, MF, or other type of (cutaneous) lymphoma ▸ No extracutaneous localizations at the time of diagnosis, as assessed with adequate staging. | Anaplastic ▸ Diffuse (n = 55) ▸ LyP-like (n = 10) Nonanaplastic ▸ Pleomorphic (n = 12) ▸ Immunoblastic (n = 2) |
| Group 3 CD30+ LTCL presenting with skin lesions and 1 involved regional lymph node station (n = 11) | ▸ Selection criteria of group 2 ▸ Histologically confirmed involvement of 1 regional lymph node station. | Anaplastic ▸ Diffuse (n = 8) ▸ LyP-like (n = 1) Nonanaplastic ▸ Pleomorphic (n = 2) |
| Group 4 Secondary cutaneous CD30+ large T-cell lymphoma (n = 11) | ▸ CD30+(anaplastic) LTCL ▸ Patients with concurrent cutaneous and extracutaneous disease (other than 1 regional lymph node) (n = 7) or ▸ Systemic CD30+(anaplastic) LTCL developing specific skin lesions during follow-up (n = 4) | Anaplastic ▸ Diffuse (n = 8) Nonanaplastic ▸ Pleomorphic (n = 3) |
| Category . | Diagnostic criteria . | Histologic subtype . |
|---|---|---|
| Group 1 Lymphomatoid papulosis (n = 118) | ▸ Recurrent, self-healing papulonodular eruption. ▸ Note: spontaneous complete remission of every individual skin lesion, irrespective of the appearance of new lesions. ▸ Histologic features suggesting (CD30+) CTCL. | LyP, type A: (n = 93) LyP, type B: (n = 6) LyP, type C: (n = 8) LyP, mixed (A, B, or both): (n = 11) |
| Group 2 Primary cutaneous CD30+ large T-cell lymphoma (n = 79) | ▸ Most (>75%) or large clusters of neoplastic cells express the CD30 antigen and have a T- or null cell phenotype ▸ No clinical evidence of LyP ▸ No prior or concurrent LyP, MF, or other type of (cutaneous) lymphoma ▸ No extracutaneous localizations at the time of diagnosis, as assessed with adequate staging. | Anaplastic ▸ Diffuse (n = 55) ▸ LyP-like (n = 10) Nonanaplastic ▸ Pleomorphic (n = 12) ▸ Immunoblastic (n = 2) |
| Group 3 CD30+ LTCL presenting with skin lesions and 1 involved regional lymph node station (n = 11) | ▸ Selection criteria of group 2 ▸ Histologically confirmed involvement of 1 regional lymph node station. | Anaplastic ▸ Diffuse (n = 8) ▸ LyP-like (n = 1) Nonanaplastic ▸ Pleomorphic (n = 2) |
| Group 4 Secondary cutaneous CD30+ large T-cell lymphoma (n = 11) | ▸ CD30+(anaplastic) LTCL ▸ Patients with concurrent cutaneous and extracutaneous disease (other than 1 regional lymph node) (n = 7) or ▸ Systemic CD30+(anaplastic) LTCL developing specific skin lesions during follow-up (n = 4) | Anaplastic ▸ Diffuse (n = 8) Nonanaplastic ▸ Pleomorphic (n = 3) |
LyP, type A: scattered CD30+ blast cells in an extensive inflammatory infiltrate.
LyP, type B: mycosis fungoides-like histology with atypical CD30− T cells with cerebriform nuclei.
LyP, type C: large clusters of CD30+ cells with few inflammatory cells, histologically suggesting a CD30+(anaplastic) large cell lymphoma.
LyP-like: anaplastic large T-cell lymphomas with relatively few CD30+ tumor cells in an extensive inflammatory infiltrate, histologically suggesting LyP.