Effect of Bcl-2-AS on cell proliferation of primary acute myeloid leukemia in vitro
| . | S-phase cells (%) . | |
|---|---|---|
| Bcl-2-AS . | NS . | |
| AML 1 | 17.7 | 11.8 |
| AML 2 | 18.4 | 13.2 |
| AML 3 | 15.4 | 9.3 |
| AML 4 | 17.2 | 13.3 |
| AML 5 | 3.1 | 1.7 |
| AML 6 | 2.4 | 4.5 |
| P-value | 0.04 | |
| . | S-phase cells (%) . | |
|---|---|---|
| Bcl-2-AS . | NS . | |
| AML 1 | 17.7 | 11.8 |
| AML 2 | 18.4 | 13.2 |
| AML 3 | 15.4 | 9.3 |
| AML 4 | 17.2 | 13.3 |
| AML 5 | 3.1 | 1.7 |
| AML 6 | 2.4 | 4.5 |
| P-value | 0.04 | |
AML, acute myeloid leukemia; Bcl-2-AS, Bcl-2 antisense oligodeoxynucleotides; NS, nonsense oligodeozynucleotides.
The percentage of cells in S-phase of the cell cycle was analyzed using the ModFit program after acridine orange staining. In 5 of 6 samples analyzed, S-phase increased.