Expression of Bcl-2 family members in primary acute myeloid leukemia treated with Bcl-2-AS by Western blot analysis
| . | Bcl-2-AS sensitive (group I) (N = 4) . | Bcl-2-AS resistant (group II) (N = 2) . |
|---|---|---|
| Anti | ||
| Bcl-XL | 3/4 | 2/2 |
| Bag-1 | 4/4 | 2/2 |
| A1 | 4/4 | 2/2 |
| Mcl-1 | 1/1 | 1/1 |
| Pro | ||
| Bax | 4/4 | 2/2 |
| Bad | 4/4 | 1/2 |
| Bak | 3/4 | 2/2 |
| . | Bcl-2-AS sensitive (group I) (N = 4) . | Bcl-2-AS resistant (group II) (N = 2) . |
|---|---|---|
| Anti | ||
| Bcl-XL | 3/4 | 2/2 |
| Bag-1 | 4/4 | 2/2 |
| A1 | 4/4 | 2/2 |
| Mcl-1 | 1/1 | 1/1 |
| Pro | ||
| Bax | 4/4 | 2/2 |
| Bad | 4/4 | 1/2 |
| Bak | 3/4 | 2/2 |
Bcl-2-AS, Bcl-2 antisense oligodeoxynucleotides.
Expression of anti- (Bcl-XL, Bag-1, A1, Mcl-1) and pro- (Bad, Bak, Bax) apoptotic members of Bcl-2 protein family was analyzed by Western blot analysis as described in “Materials and methods.” The results are presented as the number of positive samples.