Patient characteristics
| . | All patients (n = 1329) . | Patients with S pneumoniae sepsis (n = 31) . |
|---|---|---|
| Median age (y) at BMT (range, y) | 25 (1-61) | 22 (2-49) |
| Sex (M/F) | 800/529 | 19/12 |
| Diagnosis | ||
| Acute myeloid leukemia | 615 | 18 |
| Acute lymphoblastic leukemia | 339 | 7 |
| Chronic myeloid leukemia | 143 | 2 |
| Other | 232 | 3 |
| Median time (mo) from BMT (range, mo) | 10 (3-187) | |
| Type of BMT | ||
| Allograft | 918 | 26 |
| Donor | ||
| Matched sibling | 754 | 24 |
| Mismatched family | 91 | 0 |
| Matched unrelated | 73 | 2 |
| Total-body irradiation | ||
| Yes | 755 | 22 |
| No | 163 | 4 |
| GVHD prophylaxis | ||
| Cyclosporine alone | 525 | 21 |
| Methotrexate ± cyclosporine | 393 | 5 |
| Autograft | 411 | 5 |
| Total-body irradiation | ||
| Yes | 284 | 5 |
| No | 127 | 0 |
| Conditioning regimen | ||
| Total-body irradiation | 1039 | 27 |
| Chemotherapy only | 290 | 4 |
| . | All patients (n = 1329) . | Patients with S pneumoniae sepsis (n = 31) . |
|---|---|---|
| Median age (y) at BMT (range, y) | 25 (1-61) | 22 (2-49) |
| Sex (M/F) | 800/529 | 19/12 |
| Diagnosis | ||
| Acute myeloid leukemia | 615 | 18 |
| Acute lymphoblastic leukemia | 339 | 7 |
| Chronic myeloid leukemia | 143 | 2 |
| Other | 232 | 3 |
| Median time (mo) from BMT (range, mo) | 10 (3-187) | |
| Type of BMT | ||
| Allograft | 918 | 26 |
| Donor | ||
| Matched sibling | 754 | 24 |
| Mismatched family | 91 | 0 |
| Matched unrelated | 73 | 2 |
| Total-body irradiation | ||
| Yes | 755 | 22 |
| No | 163 | 4 |
| GVHD prophylaxis | ||
| Cyclosporine alone | 525 | 21 |
| Methotrexate ± cyclosporine | 393 | 5 |
| Autograft | 411 | 5 |
| Total-body irradiation | ||
| Yes | 284 | 5 |
| No | 127 | 0 |
| Conditioning regimen | ||
| Total-body irradiation | 1039 | 27 |
| Chemotherapy only | 290 | 4 |
The autograft group included 19 recipients of syngeneic transplants, 1 of whom had pneumococcal sepsis.