Detection of HGV and HCV sequences in bone marrow and serum from 48 patients
| Diagnosis . | Total . | Bone marrow . | Serum* . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HGV RNA . | HCV RNA . | HGV RNA . | HCV RNA . | Anti-HGV . | Anti-HCV . | ||||
| (+) . | (−) . | (+) . | (−) . | ||||||
| Chronic hepatitis C† | 15 | 4 | 2 | 10 | 2 | 3 | 12 | 4 | 15 |
| Chronic hepatitis B† | 4 | 1 | 0 | 0 | 0 | 1 | 0 | 3 | 0 |
| Cryptogenic cirrhosis† | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alcoholic liver disease† | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Polycythemia vera | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| Secondary polycythemia | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
| Multiple myeloma | 6 | 1 | 1 | 2 | 0 | 0 | 2 | 4 | 2 |
| Monoclonal gammopathy | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anemias | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 3 |
| Chronic myelogenous leukemia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chronic lymphocytic leukemia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Acute myeoloblastic leukemia | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
| Unexplained leukopenia and/or thrombocytopenia | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 3 | 0 |
| Other‡ | 3 | 0 | 0 | 1 | 1 | 0 | 2 | 1 | 2 |
| Diagnosis . | Total . | Bone marrow . | Serum* . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HGV RNA . | HCV RNA . | HGV RNA . | HCV RNA . | Anti-HGV . | Anti-HCV . | ||||
| (+) . | (−) . | (+) . | (−) . | ||||||
| Chronic hepatitis C† | 15 | 4 | 2 | 10 | 2 | 3 | 12 | 4 | 15 |
| Chronic hepatitis B† | 4 | 1 | 0 | 0 | 0 | 1 | 0 | 3 | 0 |
| Cryptogenic cirrhosis† | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alcoholic liver disease† | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Polycythemia vera | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| Secondary polycythemia | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
| Multiple myeloma | 6 | 1 | 1 | 2 | 0 | 0 | 2 | 4 | 2 |
| Monoclonal gammopathy | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anemias | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 3 |
| Chronic myelogenous leukemia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chronic lymphocytic leukemia | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Acute myeoloblastic leukemia | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
| Unexplained leukopenia and/or thrombocytopenia | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 3 | 0 |
| Other‡ | 3 | 0 | 0 | 1 | 1 | 0 | 2 | 1 | 2 |
HGV RNA = hepatitis G virus; HCV RNA = hepatitis C virus.
HGV RNA and HCV RNA negative strands were not detected in any serum samples.
Patients with liver disease presented with leuko- and/or thrombocytopenia or leukocytosis.
One case each of toxocariasis, mesothelioma, and prostatic carcinoma; in the latter 2 cases, the patients presented with thrombocytopenia.