Anti-EBV and anti-allo frequencies, including confidence intervals of unsorted, NIT+, and NIT− T cells of donor S.B. and U.S. after gene transfer on days 5, 8, or 23 and further processing as described
| . | Frequency unsorted . | Confidence interval . | Frequency NIT+ . | Confidence interval . | Frequency NIT− . | Confidence interval . |
|---|---|---|---|---|---|---|
| Donor S.B., day 5 | ||||||
| Anti-EBV | 1/1362 | 1/1156-1/1659 | 1/1236 | 1/1063-1/1477 | 1/4432 | 1/3654-1/5878 |
| Anti-allo | 1/1452 | 1/1282-1/1674 | 1/3888 | 1/3124-1/4976 | 1/6132 | 1/5413-1/7069 |
| Ratio | 1:1 | 3:1 | 1.4:1 | |||
| Donor S.B., day 8 | ||||||
| Anti-EBV | 1/9630 | 1/7483-1/13 694 | 1/1577 | 1/1372-1/1854 | 1/13 645 | 1/9327-1/14 163 |
| Anti-allo | 1/9507 | 1/8241-1/11 232 | 1/114 716 | 1/71 118-1/296 446 | 1/12 431 | 1/10 833-1/15 494 |
| Ratio | 1:1 | 72:1 | 1:1 | |||
| Donor S.B., day 23 | ||||||
| Anti-EBV | 1/2314 | 1/1864-1/3328 | 1/1289 | 1/1074-1/1563 | 1/7633 | 1/5974-1/9126 |
| Anti-allo | 1/120 886 | 1/74 634-1/310 089 | < 1/500 000 | < 1/500 000 | 1/144 613 | 1/88 365-1/397 045 |
| Ratio | 52:1 | > 400:1 | 19:1 | |||
| Donor U.S., day 5 | ||||||
| Anti-EBV | 1/2393 | 1/1980-1/2656 | 1/1243 | 1/1019-1/1593 | 1/6314 | 1/5937-1/6980 |
| Anti-allo | 1/5929 | 1/5194-1/6947 | 1/8271 | 1/7603-1/8931 | 1/5260 | 1/4643-1/6065 |
| Ratio | 2.4:1 | 6:1 | 1:1 | |||
| Donor U.S., day 8 | ||||||
| Anti-EBV | 1/2883 | 1/2396-1/3418 | 1/755 | 1/609-1/1086 | 1/8462 | 1/6245-1/11 479 |
| Anti-allo | 1/14 621 | 1/11 278-1/20 186 | 1/66 773 | 1/48 832-1/118 494 | 1/14 800 | 1/11 978-1/20 465 |
| Ratio | 5:1 | 88:1 | 1.7:1 | |||
| Donor U.S., day 23 | ||||||
| Anti-EBV | 1/1470 | 1/1302-1/1687 | 1/1599 | 1/1411-1/1864 | 1/4954 | 1/3823-1/6105 |
| Anti-allo | 1/62 650 | 1/43 518-1/111 803 | < 1/500 000 | < 1/500 000 | 1/126 615 | 1/78 081-1/334 587 |
| Ratio | 42:1 | > 400:1 | 25:1 |
| . | Frequency unsorted . | Confidence interval . | Frequency NIT+ . | Confidence interval . | Frequency NIT− . | Confidence interval . |
|---|---|---|---|---|---|---|
| Donor S.B., day 5 | ||||||
| Anti-EBV | 1/1362 | 1/1156-1/1659 | 1/1236 | 1/1063-1/1477 | 1/4432 | 1/3654-1/5878 |
| Anti-allo | 1/1452 | 1/1282-1/1674 | 1/3888 | 1/3124-1/4976 | 1/6132 | 1/5413-1/7069 |
| Ratio | 1:1 | 3:1 | 1.4:1 | |||
| Donor S.B., day 8 | ||||||
| Anti-EBV | 1/9630 | 1/7483-1/13 694 | 1/1577 | 1/1372-1/1854 | 1/13 645 | 1/9327-1/14 163 |
| Anti-allo | 1/9507 | 1/8241-1/11 232 | 1/114 716 | 1/71 118-1/296 446 | 1/12 431 | 1/10 833-1/15 494 |
| Ratio | 1:1 | 72:1 | 1:1 | |||
| Donor S.B., day 23 | ||||||
| Anti-EBV | 1/2314 | 1/1864-1/3328 | 1/1289 | 1/1074-1/1563 | 1/7633 | 1/5974-1/9126 |
| Anti-allo | 1/120 886 | 1/74 634-1/310 089 | < 1/500 000 | < 1/500 000 | 1/144 613 | 1/88 365-1/397 045 |
| Ratio | 52:1 | > 400:1 | 19:1 | |||
| Donor U.S., day 5 | ||||||
| Anti-EBV | 1/2393 | 1/1980-1/2656 | 1/1243 | 1/1019-1/1593 | 1/6314 | 1/5937-1/6980 |
| Anti-allo | 1/5929 | 1/5194-1/6947 | 1/8271 | 1/7603-1/8931 | 1/5260 | 1/4643-1/6065 |
| Ratio | 2.4:1 | 6:1 | 1:1 | |||
| Donor U.S., day 8 | ||||||
| Anti-EBV | 1/2883 | 1/2396-1/3418 | 1/755 | 1/609-1/1086 | 1/8462 | 1/6245-1/11 479 |
| Anti-allo | 1/14 621 | 1/11 278-1/20 186 | 1/66 773 | 1/48 832-1/118 494 | 1/14 800 | 1/11 978-1/20 465 |
| Ratio | 5:1 | 88:1 | 1.7:1 | |||
| Donor U.S., day 23 | ||||||
| Anti-EBV | 1/1470 | 1/1302-1/1687 | 1/1599 | 1/1411-1/1864 | 1/4954 | 1/3823-1/6105 |
| Anti-allo | 1/62 650 | 1/43 518-1/111 803 | < 1/500 000 | < 1/500 000 | 1/126 615 | 1/78 081-1/334 587 |
| Ratio | 42:1 | > 400:1 | 25:1 |
The anti-auto:anti-allo frequency ratio is indicated below each experiment.