Life table analysis of malignant transformation in a cohort of 352 patients with congenital neutropenia
| Interval, y . | Patients at onset (without MDS/AML) . | Patients censored . | Patients at risk of MDS/AML . | Patients with MDS/AML . | Proportion of MDS/AML . | Cumulative proportion without MDS/AML (standard error) . | Hazard rate, % . |
|---|---|---|---|---|---|---|---|
| 0-1 | 352 | 45 | 329.5 | 3 | 0.0091 | 1.000 | 0.9 |
| (0.0000) | |||||||
| 1-2 | 303 | 42 | 282 | 2 | 0.0071 | 0.9909 | 0.7 |
| (0.0052) | |||||||
| 2-3 | 259 | 29 | 244.5 | 3 | 0.0123 | 0.9838 | 1.2 |
| (0.0072) | |||||||
| 3-4 | 227 | 28 | 214 | 3 | 0.0141 | 0.9718 | 1.4 |
| (0.0099) | |||||||
| 4-5 | 196 | 27 | 182.5 | 5 | 0.0274 | 0.9581 | 2.7 |
| (0.0125) | |||||||
| 5-6 | 164 | 17 | 155.5 | 1 | 0.0064 | 0.9318 | 0.6 |
| (0.0168) | |||||||
| 6-7 | 146 | 24 | 134 | 6 | 0.0448 | 0.9258 | 4.4 |
| (0.0177) | |||||||
| 7-8 | 116 | 41 | 95.5 | 3 | 0.0314 | 0.8844 | 3.1 |
| (0.0237) | |||||||
| 8-9 | 72 | 22 | 59 | 5 | 0.0847 | 0.8566 | 8.4 |
| (0.0278) | |||||||
| 9-10 | 41 | 35 | 23.5 | 0 | 0.000 | 0.7840 | 0.0 |
| (0.0402) | |||||||
| 10-11 | 6 | 6 | 3 | 0 | 0.000 | 0.7840 | 0.0 |
| (0.0402) |
| Interval, y . | Patients at onset (without MDS/AML) . | Patients censored . | Patients at risk of MDS/AML . | Patients with MDS/AML . | Proportion of MDS/AML . | Cumulative proportion without MDS/AML (standard error) . | Hazard rate, % . |
|---|---|---|---|---|---|---|---|
| 0-1 | 352 | 45 | 329.5 | 3 | 0.0091 | 1.000 | 0.9 |
| (0.0000) | |||||||
| 1-2 | 303 | 42 | 282 | 2 | 0.0071 | 0.9909 | 0.7 |
| (0.0052) | |||||||
| 2-3 | 259 | 29 | 244.5 | 3 | 0.0123 | 0.9838 | 1.2 |
| (0.0072) | |||||||
| 3-4 | 227 | 28 | 214 | 3 | 0.0141 | 0.9718 | 1.4 |
| (0.0099) | |||||||
| 4-5 | 196 | 27 | 182.5 | 5 | 0.0274 | 0.9581 | 2.7 |
| (0.0125) | |||||||
| 5-6 | 164 | 17 | 155.5 | 1 | 0.0064 | 0.9318 | 0.6 |
| (0.0168) | |||||||
| 6-7 | 146 | 24 | 134 | 6 | 0.0448 | 0.9258 | 4.4 |
| (0.0177) | |||||||
| 7-8 | 116 | 41 | 95.5 | 3 | 0.0314 | 0.8844 | 3.1 |
| (0.0237) | |||||||
| 8-9 | 72 | 22 | 59 | 5 | 0.0847 | 0.8566 | 8.4 |
| (0.0278) | |||||||
| 9-10 | 41 | 35 | 23.5 | 0 | 0.000 | 0.7840 | 0.0 |
| (0.0402) | |||||||
| 10-11 | 6 | 6 | 3 | 0 | 0.000 | 0.7840 | 0.0 |
| (0.0402) |
The number of patients censored indicates the number of patients starting the year interval but not yet completing it. The number of effective patients at risk indicates that n is the number of patients who start, minus one-half n censored. The assumption is that half of n censored do not reach the half-year point. The proportion of MDS/AML indicates the number of patients with MDS/AML divided by the effective n at risk. Hazard rate indicates the number of patients with MDS/AML divided by the effective n at risk times 100.