Toxicity
| Adverse events (grades 3, 4) . | Cells + IL-2 (n = 11) . | Cells only (n = 13) . | Total (n = 24) . |
|---|---|---|---|
| Clinical3-150 | |||
| Fever | 1 | 0 | 1 |
| Nausea | 1 | 0 | 1 |
| Vomiting | 1 | 0 | 1 |
| Dehydration | 1 | 0 | 1 |
| Arthralgia | 1 | 0 | 1 |
| Myalgia | 1 | 0 | 1 |
| Headache | 0 | 1 | 1 |
| Dyspnea | 1 | 0 | 1 |
| Cellulitis | 1 | 0 | 1 |
| Laboratory | |||
| Phosphate <1.5 mg/dL | 1 | 0 | 1 |
| AST >165 U/L | 0 | 1 | 1 |
| GGT >350 U/L | 1 | 0 | 1 |
| Glucose >250 mg/dL | 0 | 1 | 1 |
| Adverse events (grades 3, 4) . | Cells + IL-2 (n = 11) . | Cells only (n = 13) . | Total (n = 24) . |
|---|---|---|---|
| Clinical3-150 | |||
| Fever | 1 | 0 | 1 |
| Nausea | 1 | 0 | 1 |
| Vomiting | 1 | 0 | 1 |
| Dehydration | 1 | 0 | 1 |
| Arthralgia | 1 | 0 | 1 |
| Myalgia | 1 | 0 | 1 |
| Headache | 0 | 1 | 1 |
| Dyspnea | 1 | 0 | 1 |
| Cellulitis | 1 | 0 | 1 |
| Laboratory | |||
| Phosphate <1.5 mg/dL | 1 | 0 | 1 |
| AST >165 U/L | 0 | 1 | 1 |
| GGT >350 U/L | 1 | 0 | 1 |
| Glucose >250 mg/dL | 0 | 1 | 1 |
AST indicates aspartate aminotransferase; GGT, gamma-glutamyl transferase.
The following grade-2 clinical adverse events were noted in more than 1 patient: fever (6), chills (4), pain (4), myalgia (3), headache (3), rash (3), flu syndrome (2), sinusitis (2), diaphoresis (2), malaise (2), phlebitis (2), anorexia (2), diarrhea (2), nausea (2), and lymphadenopathy (2). Of these, only chills (2), fever (2), rash (2), sinusitis (2), and pain (1) were noted in the cells-only group.