Table 3. Relationship between clinical... | American Society of Hematology

Table 3.

Relationship between clinical and biological variables and treatment outcome

	Patients, no.	CR, %	P^3-150,^3-151	P^3-152	3-y DFS, %/median d	P^3-150,^3-153	P^3-152	3-y OS, %/median d	P^3-150,^3-153	P^3-152
Panmyeloid antigens			<.0001	.02		.02	.04		.008	.04
+	50	80			52/NR			48/680
−	127	48			16/390			17/231
Age			<.0001	.001		.01	.02		<.0001	.002
<60	80	35			14/290			19/164
≥60	97	75			41/580			43/784
WHO performance status			.01	.01		.01	.03		.005	.02
<2	133	62			40/439			37/484
≥2	44	41			14/392			20/180
Cytogenetic			.005	NS		.01	NS		.01	NS
Good	22	82			59/NR			53
Intermediate	113	59			33/518			31/345
Poor	32	34			12/189			19/201
Failure or not done	10	50
FAB subtypes			NS	NS		NS	NS		NS	NS
M0	4	75			0/170			20/170
M1	35	54			0/130			0/185
M2	63	59			34/579			34/531
M4	35	54			60/NR			51/NR
M4E	7	86			40/380			50/NR
M5	25	52			22/170			21/190
M6	7	57			0/227			40/200
WBC count, ×10⁹/L			NS	NS		NS	NS		NS	NS
≥30	59	47			29/430			23/295
<30	118	62			38/588			36/300
LDH level, U/L			NS	NS		NS	NS		NS	NS
≥2000	48	46			32/350			32/277
<2000	129	61			33/537			34/599
Pgp expression^3-155			NS	NS		NS	NS		NS	NS
+	87	50			14/370			16/286
−	90	63			37/352			24/245
Pgp activity (n = 150)^3-154			.04	.05		.04	.05		.04	.05
+	48	50			0/321			8/231
−	102	68			14/360			33/348

	Patients, no.	CR, %	P^3-150,^3-151	P^3-152	3-y DFS, %/median d	P^3-150,^3-153	P^3-152	3-y OS, %/median d	P^3-150,^3-153	P^3-152
Panmyeloid antigens			<.0001	.02		.02	.04		.008	.04
+	50	80			52/NR			48/680
−	127	48			16/390			17/231
Age			<.0001	.001		.01	.02		<.0001	.002
<60	80	35			14/290			19/164
≥60	97	75			41/580			43/784
WHO performance status			.01	.01		.01	.03		.005	.02
<2	133	62			40/439			37/484
≥2	44	41			14/392			20/180
Cytogenetic			.005	NS		.01	NS		.01	NS
Good	22	82			59/NR			53
Intermediate	113	59			33/518			31/345
Poor	32	34			12/189			19/201
Failure or not done	10	50
FAB subtypes			NS	NS		NS	NS		NS	NS
M0	4	75			0/170			20/170
M1	35	54			0/130			0/185
M2	63	59			34/579			34/531
M4	35	54			60/NR			51/NR
M4E	7	86			40/380			50/NR
M5	25	52			22/170			21/190
M6	7	57			0/227			40/200
WBC count, ×10⁹/L			NS	NS		NS	NS		NS	NS
≥30	59	47			29/430			23/295
<30	118	62			38/588			36/300
LDH level, U/L			NS	NS		NS	NS		NS	NS
≥2000	48	46			32/350			32/277
<2000	129	61			33/537			34/599
Pgp expression^3-155			NS	NS		NS	NS		NS	NS
+	87	50			14/370			16/286
−	90	63			37/352			24/245
Pgp activity (n = 150)^3-154			.04	.05		.04	.05		.04	.05
+	48	50			0/321			8/231
−	102	68			14/360			33/348

NR indicates not reached; NS indicates not significant.

Indicates univariate analysis.

Indicates that the Fisher exact test was used.

Indicates multivariate analysis.

Indicates that the log-rank test was used.

Staining with UIC2 was considered positive when D ≥ 0.15. This D value cutoff point was derived based on observations of previous works.21

Uptake of calcein-am was considered positive when D ≥ 0.3. This D value cutoff point was derived based on observations of previous works.21