Table 3. Frequency of selected... | American Society of Hematology

Table 3.

Frequency of selected chromosome abnormalities in this and other studies of T-ALL

	Current study	Heerema et al¹⁰	GFCH¹⁶^3-150	Raimondi et al¹⁷	GFCH¹⁸^3-150	Berger et al¹⁹	Kaneko et al²⁰	Gladstone et al²¹	Secker-Walker et al²²	Uckun et al²³^3-150	Rowley et al²⁴
	2000	1998	1996	1988	1993	1990	1989	1998	1992	1989	1999
Total karyotyped	354	169C	95A	57C	56C	44A,C	33C	30A,C	19A,C	26C	15A,C
Normal, no. (% of total)	153 (43)	66 (39)	23 (24)	16 (28)	22 (39)	11 (25)	9 (27)	3 (10)	4 (21)	12 (46)	5 (33)
Abnormal, No.	201	103	72	41	34	33	24	27	15	14	10
Chromosomal abnormalities, %
14q11-13^3-151	21.9	28	34.7	15	11.8	21	42	6.6	47	29	10
del(6q)	18.9	30	19.4^3-152	22	26^3-152	12	25	40	13	22	40
+8	10.9	10.7	5.6	2.4	NR	3	—	3.3	—	NR	—
del(9p), incl. i(9q)	9.5	14.6	20.8^3-152	20	29^3-152	6	17	10	13	7	30
7q32-36	7.5	7.8	NR	5	2.9	3	—	10	7	7	20
t(11;14)(p13;q11)	7.0	12.6	NR	7.3	5.9	9	21	6.6	7	14	10
t(10;14)(q24;q11)	6.0	2.9	18.1	2.4	2.9	—	—	—	7	7	—
del(5q)	5.5	1.9	NR	2.4	11.8	6	8	3.3	—	—	10
del(11q)	4.5	5.8	NR	7.3	NR	9	—	6.6	7	—	—
del(12p)	4.5	3.9	5.6^3-152	5	5.9^3-152	24	4	6.6	—	14	10
7p15	4	3.9	NR	2.4	—	3	12.5	—	—	7	10
14q32	2	8.7	NR	2.4	NR	6	4	10	—	7	30

	Current study	Heerema et al¹⁰	GFCH¹⁶^3-150	Raimondi et al¹⁷	GFCH¹⁸^3-150	Berger et al¹⁹	Kaneko et al²⁰	Gladstone et al²¹	Secker-Walker et al²²	Uckun et al²³^3-150	Rowley et al²⁴
	2000	1998	1996	1988	1993	1990	1989	1998	1992	1989	1999
Total karyotyped	354	169C	95A	57C	56C	44A,C	33C	30A,C	19A,C	26C	15A,C
Normal, no. (% of total)	153 (43)	66 (39)	23 (24)	16 (28)	22 (39)	11 (25)	9 (27)	3 (10)	4 (21)	12 (46)	5 (33)
Abnormal, No.	201	103	72	41	34	33	24	27	15	14	10
Chromosomal abnormalities, %
14q11-13^3-151	21.9	28	34.7	15	11.8	21	42	6.6	47	29	10
del(6q)	18.9	30	19.4^3-152	22	26^3-152	12	25	40	13	22	40
+8	10.9	10.7	5.6	2.4	NR	3	—	3.3	—	NR	—
del(9p), incl. i(9q)	9.5	14.6	20.8^3-152	20	29^3-152	6	17	10	13	7	30
7q32-36	7.5	7.8	NR	5	2.9	3	—	10	7	7	20
t(11;14)(p13;q11)	7.0	12.6	NR	7.3	5.9	9	21	6.6	7	14	10
t(10;14)(q24;q11)	6.0	2.9	18.1	2.4	2.9	—	—	—	7	7	—
del(5q)	5.5	1.9	NR	2.4	11.8	6	8	3.3	—	—	10
del(11q)	4.5	5.8	NR	7.3	NR	9	—	6.6	7	—	—
del(12p)	4.5	3.9	5.6^3-152	5	5.9^3-152	24	4	6.6	—	14	10
7p15	4	3.9	NR	2.4	—	3	12.5	—	—	7	10
14q32	2	8.7	NR	2.4	NR	6	4	10	—	7	30

A, adults; C, children; NR, not reported.

Full karyotypes are not reported.

Includes cases of t(11;14) and t(10;14).

The study reported “6q abn”, “9p abn”, or “12p abn”.