Adverse events during study period
| . | No. patients . | No. episodes (%) . |
|---|---|---|
| Decrease in Hb ≥ 1 g/dL | 19 | 74 (16) |
| Renewed RBC transfusion requirement | 10 | 26 (6) |
| Drop of ANC to < 1.5 × 109/L | 17 | 40 (9) |
| Drop of ANC to < 1 × 109/L | 7 | 12 (3) |
| Drop of ANC to < 0.5 × 109/L | 5 | 5 (1) |
| Decrease of Plts ≥ 50% | 15 | 75 (16) |
| Drop of Plts to < 20 × 109/L | 5 | 8 (2) |
| Renewed Plts transfusion requirement | 7 | 20 (4) |
| Bacterial infections | ||
| Sepsis | 7 | 9 |
| Urinary tract | 2 | 2 |
| Sinusitis | 1 | 1 |
| Ileitis | 1 | 1 |
| Fever of unknown origin | 14 | 21 |
| Viral infections | ||
| CMV reactivation | 11 | 12 |
| Herpes simplex/zoster | 7 | 14 |
| Fungal infections | ||
| Sepsis | 1 | 2 |
| Stomatitis | 4 | 4 |
| Bleeding | 3 | 3 |
| . | No. patients . | No. episodes (%) . |
|---|---|---|
| Decrease in Hb ≥ 1 g/dL | 19 | 74 (16) |
| Renewed RBC transfusion requirement | 10 | 26 (6) |
| Drop of ANC to < 1.5 × 109/L | 17 | 40 (9) |
| Drop of ANC to < 1 × 109/L | 7 | 12 (3) |
| Drop of ANC to < 0.5 × 109/L | 5 | 5 (1) |
| Decrease of Plts ≥ 50% | 15 | 75 (16) |
| Drop of Plts to < 20 × 109/L | 5 | 8 (2) |
| Renewed Plts transfusion requirement | 7 | 20 (4) |
| Bacterial infections | ||
| Sepsis | 7 | 9 |
| Urinary tract | 2 | 2 |
| Sinusitis | 1 | 1 |
| Ileitis | 1 | 1 |
| Fever of unknown origin | 14 | 21 |
| Viral infections | ||
| CMV reactivation | 11 | 12 |
| Herpes simplex/zoster | 7 | 14 |
| Fungal infections | ||
| Sepsis | 1 | 2 |
| Stomatitis | 4 | 4 |
| Bleeding | 3 | 3 |
Hb indicates hemoglobin; RBC, red blood cells; ANC, absolute neutrophil counts; Plts, platelets; CMV, cytomegalovirus.