Analysis of MGUS patients' sera for IgG antibody to HHV-8 lytic antigens by ELISA to whole virus*
| MGUS patients' sera . | No. tested . | No. positive . | % positive† . |
|---|---|---|---|
| No progression to serious disease‡ | 268 | 21 | 7.8 |
| Progression to serious disease in less than 5 years | 60 | 3 | 5.0 |
| Progression to serious disease in more than 5 years | 34 | 2 | 5.9 |
| MGUS patients' sera . | No. tested . | No. positive . | % positive† . |
|---|---|---|---|
| No progression to serious disease‡ | 268 | 21 | 7.8 |
| Progression to serious disease in less than 5 years | 60 | 3 | 5.0 |
| Progression to serious disease in more than 5 years | 34 | 2 | 5.9 |
Sera were tested against the HHV-8 virus by ELISA at Advanced Biotechnologies Inc. This preparation of the ELISA antigen contained 1.8 × 109 viral particles per liter and 1.08 mg/mL of protein.
Antibody-positive samples were confirmed by IFA to HHV-8 lytic antigens, using the procedure of Chatlynne et al.22
Serious diseases such as MM, amyloidosis, or Waldenström macroglobulinemia.