Table 2. Cellular drug resistance assay... | American Society of Hematology

Table 2.

Cellular drug resistance assay characteristics showing differences between AML and ALL and the several AML FAB-type subgroups

Assay characteristics	AML	ALL	P^*	FAB M1/2	FAB M4	FAB M5	P^† M1/2-M4	P^†M1/2-M5	P^† M4-M5
Blasts d4, %	87	89	.02	83	85	89	.43	.02	.06
CCS, median	99	64	< .001	91	106	87	.07	.75	.15
(range), %	(66-211)	(13-201)		(45-168)	(48-211)	(28-184)
OD/10⁵cells,	0.51	0.23	< .001	0.45	0.62	0.62	< .001	.003	.40
median (range), %	(0.12-1.16)	(0.05-0.66)		(0.12-0.73)	(0.29-1.16)	(0.28-1.11)

Assay characteristics	AML	ALL	P^*	FAB M1/2	FAB M4	FAB M5	P^† M1/2-M4	P^†M1/2-M5	P^† M4-M5
Blasts d4, %	87	89	.02	83	85	89	.43	.02	.06
CCS, median	99	64	< .001	91	106	87	.07	.75	.15
(range), %	(66-211)	(13-201)		(45-168)	(48-211)	(28-184)
OD/10⁵cells,	0.51	0.23	< .001	0.45	0.62	0.62	< .001	.003	.40
median (range), %	(0.12-1.16)	(0.05-0.66)		(0.12-0.73)	(0.29-1.16)	(0.28-1.11)

The percentage of blasts d4 and CCS indicate the percentage of blasts and the median CCS, respectively, in the control wells after 4 days of culture.

Statistical differences between AML and ALL.

Statistical differences between the FAB-type subgroups in AML.