Univariate log-linear regression model showing rate ratio of NHL incidence
| Variable . | Total no. of HIV patients (n = 7840) . | NHL cases (%) (n = 150) . | Incidence NHL per 10 000 patient-years . | Rate ratio . | 95% CI . | Likelihood ratio . | df . | P value . | |
|---|---|---|---|---|---|---|---|---|---|
| Gender | Female | 618 | 6 (1.0) | 4.9 | 0.57 | (0.25 to 1.29) | 2.15 | 1 | .143 |
| Male | 7222 | 144 (2.0) | 8.5 | 1 | |||||
| Ethnic group | Missing | 1653 | 24 (1.5) | 6.9 | 0.76 | (0.48 to 1.19) | 1.98 | 2 | .372 |
| Non-white | 1878 | 31 (1.7) | 7.5 | 0.83 | (0.55 to 1.24) | ||||
| White | 4309 | 95 (2.2) | 9.1 | 1 | |||||
| IVDU | Yes | 580 | 8 (1.4) | 5.8 | 0.69 | (0.34 to 1.40) | 1.20 | 1 | .274 |
| No | 7620 | 142 (2.0) | 8.5 | 1 | |||||
| Age at entry (y) | 1.04 | (1.03 to 1.06) | 38.83 | 4 | <.001 | ||||
| Age at entry (y)3-150 | Missing | 92 | 0 | 0 | — | — | 44.64 | 1 | <.001 |
| >37 | 2126 | 66 (3.1) | 15.3 | 3.29 | (2.02 to 5.39) | ||||
| 32-37 | 1818 | 25 (1.4) | 6.4 | 1.38 | (0.77 to 2.46) | ||||
| 27-31 | 2016 | 38 (1.9) | 8.2 | 1.76 | (1.03 to 3.00) | ||||
| ≤26 | 1788 | 21 (1.2) | 4.7 | 1 | |||||
| Year of entry to study | ≤1985 | 1090 | 26 (2.4) | 7.2 | 0.85 | (0.45 to 1.64) | 0.65 | 3 | .884 |
| 1986-90 | 3039 | 64 (2.1) | 8.5 | 1.00 | (0.56 to 1.79) | ||||
| 1991-95 | 2470 | 46 (1.9) | 8.6 | 1.01 | (0.56 to 1.84) | ||||
| ≥1996 | 1241 | 14 (1.1) | 8.5 | 1 | |||||
| First ever CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.33 | (0.13 to 0.83) | 30.31 | 4 | <.001 |
| (cells/μL)3-150 | ≥484 | 1716 | 21 (1.2) | 4.6 | 0.32 | (0.20 to 0.54) | |||
| 305-483 | 1708 | 26 (1.5) | 5.7 | 0.41 | (0.25 to 0.65) | ||||
| 122-304 | 1715 | 46 (2.7) | 10.7 | 0.76 | (0.51 to 1.13) | ||||
| ≤121 | 1725 | 52 (3.) | 14.1 | 1 | |||||
| Nadir CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.34 | (0.14 to 0.84) | 78.53 | 4 | <.001 |
| (cells/μL)3-150 | ≥291 | 1708 | 2 (0.1) | 0.5 | 0.04 | (0.01 to 0.16) | |||
| 115-290 | 1718 | 24 (1.4) | 5.4 | 0.39 | (0.24 to 0.62) | ||||
| 17-114 | 1669 | 55 (3.3) | 12.9 | 0.93 | (0.65 to 1.34) | ||||
| ≤16 | 1769 | 64 (3.6) | 13.9 | 1 | |||||
| Nadir CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.47 | (0.19 to 1.15) | 37.85 | 2 | <.001 |
| (cells/μL) | >350 | 1268 | 2 (0.2) | 0.7 | 0.07 | (0.02 to 0.30) | |||
| ≤350 | 5596 | 143 (2.6) | 10.0 | 1 | |||||
| HAART before NHL | No | 5642 | 133 (2.4) | 11.2 | 4.12 | (2.49 to 6.83) | 43.04 | 1 | <.001 |
| Yes | 2198 | 17 (0.8) | 2.7 | 1 | |||||
| Variable . | Total no. of HIV patients (n = 7840) . | NHL cases (%) (n = 150) . | Incidence NHL per 10 000 patient-years . | Rate ratio . | 95% CI . | Likelihood ratio . | df . | P value . | |
|---|---|---|---|---|---|---|---|---|---|
| Gender | Female | 618 | 6 (1.0) | 4.9 | 0.57 | (0.25 to 1.29) | 2.15 | 1 | .143 |
| Male | 7222 | 144 (2.0) | 8.5 | 1 | |||||
| Ethnic group | Missing | 1653 | 24 (1.5) | 6.9 | 0.76 | (0.48 to 1.19) | 1.98 | 2 | .372 |
| Non-white | 1878 | 31 (1.7) | 7.5 | 0.83 | (0.55 to 1.24) | ||||
| White | 4309 | 95 (2.2) | 9.1 | 1 | |||||
| IVDU | Yes | 580 | 8 (1.4) | 5.8 | 0.69 | (0.34 to 1.40) | 1.20 | 1 | .274 |
| No | 7620 | 142 (2.0) | 8.5 | 1 | |||||
| Age at entry (y) | 1.04 | (1.03 to 1.06) | 38.83 | 4 | <.001 | ||||
| Age at entry (y)3-150 | Missing | 92 | 0 | 0 | — | — | 44.64 | 1 | <.001 |
| >37 | 2126 | 66 (3.1) | 15.3 | 3.29 | (2.02 to 5.39) | ||||
| 32-37 | 1818 | 25 (1.4) | 6.4 | 1.38 | (0.77 to 2.46) | ||||
| 27-31 | 2016 | 38 (1.9) | 8.2 | 1.76 | (1.03 to 3.00) | ||||
| ≤26 | 1788 | 21 (1.2) | 4.7 | 1 | |||||
| Year of entry to study | ≤1985 | 1090 | 26 (2.4) | 7.2 | 0.85 | (0.45 to 1.64) | 0.65 | 3 | .884 |
| 1986-90 | 3039 | 64 (2.1) | 8.5 | 1.00 | (0.56 to 1.79) | ||||
| 1991-95 | 2470 | 46 (1.9) | 8.6 | 1.01 | (0.56 to 1.84) | ||||
| ≥1996 | 1241 | 14 (1.1) | 8.5 | 1 | |||||
| First ever CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.33 | (0.13 to 0.83) | 30.31 | 4 | <.001 |
| (cells/μL)3-150 | ≥484 | 1716 | 21 (1.2) | 4.6 | 0.32 | (0.20 to 0.54) | |||
| 305-483 | 1708 | 26 (1.5) | 5.7 | 0.41 | (0.25 to 0.65) | ||||
| 122-304 | 1715 | 46 (2.7) | 10.7 | 0.76 | (0.51 to 1.13) | ||||
| ≤121 | 1725 | 52 (3.) | 14.1 | 1 | |||||
| Nadir CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.34 | (0.14 to 0.84) | 78.53 | 4 | <.001 |
| (cells/μL)3-150 | ≥291 | 1708 | 2 (0.1) | 0.5 | 0.04 | (0.01 to 0.16) | |||
| 115-290 | 1718 | 24 (1.4) | 5.4 | 0.39 | (0.24 to 0.62) | ||||
| 17-114 | 1669 | 55 (3.3) | 12.9 | 0.93 | (0.65 to 1.34) | ||||
| ≤16 | 1769 | 64 (3.6) | 13.9 | 1 | |||||
| Nadir CD4 count | Missing | 976 | 5 (0.5) | 4.7 | 0.47 | (0.19 to 1.15) | 37.85 | 2 | <.001 |
| (cells/μL) | >350 | 1268 | 2 (0.2) | 0.7 | 0.07 | (0.02 to 0.30) | |||
| ≤350 | 5596 | 143 (2.6) | 10.0 | 1 | |||||
| HAART before NHL | No | 5642 | 133 (2.4) | 11.2 | 4.12 | (2.49 to 6.83) | 43.04 | 1 | <.001 |
| Yes | 2198 | 17 (0.8) | 2.7 | 1 | |||||
NHL = non-Hodgkin lymphoma; CI = confidence interval; df = degrees of freedom; IVDU = intravenous drug user; HAART = highly active antiretroviral therapy.
Categories presented as quartiles.