Table 1.

Intracellular Na+ and K+concentrations

DonorIntracellular electrolytes
(mmol/L cells)
Isotopic K+ influx (5 mmol/L external [K+]) (mmol/L cells · h)
[Na+][K+]Na+, K+ pump ouabain-sensitiveNa+, K+ cotransport bumetanide-sensitiveResidual leak
CL II.7 — — 3.360 0.690 0.139  
CL II.3* — — 3.455 0.889 0.186  
CL III.1 — — 3.049 0.318 0.201  
CL II.4* — — 3.750 0.700 0.145 
Control — — 2.070 0.510 0.066  
GR III.1 9.2 95.9 12.650 2.033 0.220 
VA II.2* 21.1 77.8 3.081 2.233 0.144  
VE II.5 21.7 82.2 4.965 2.007 0.204  
Travel control 15.1 96.9 — — — 
Normal 5-11 85-105 1-2 0-1 0.06-0.10 
DonorIntracellular electrolytes
(mmol/L cells)
Isotopic K+ influx (5 mmol/L external [K+]) (mmol/L cells · h)
[Na+][K+]Na+, K+ pump ouabain-sensitiveNa+, K+ cotransport bumetanide-sensitiveResidual leak
CL II.7 — — 3.360 0.690 0.139  
CL II.3* — — 3.455 0.889 0.186  
CL III.1 — — 3.049 0.318 0.201  
CL II.4* — — 3.750 0.700 0.145 
Control — — 2.070 0.510 0.066  
GR III.1 9.2 95.9 12.650 2.033 0.220 
VA II.2* 21.1 77.8 3.081 2.233 0.144  
VE II.5 21.7 82.2 4.965 2.007 0.204  
Travel control 15.1 96.9 — — — 
Normal 5-11 85-105 1-2 0-1 0.06-0.10 

Blood was always stored for at least 18 hours on ice prior to analysis. Intracellular electrolyte concentrations of family BI members, provided elsewhere,22 were consistent with values obtained in VA II.2 and VE II.5.

*

 DHS + pseudohyperkalemia.

 DHS + (personal) history of PEDHS.

or Create an Account

Close Modal
Close Modal