Table 3. Levels of MRD at the end of... | American Society of Hematology

Table 3.

Levels of MRD at the end of remission induction according to clinical and biologic features at diagnosis

Presenting feature	MRD-negative (<0.01%)	MRD-positive			P value^3-150
Presenting feature	MRD-negative (<0.01%)	≥0.01%<0.1%	≥0.1%<1%	≥1%	P value^3-150
Age (y)
<1	2	1	3	0
1-9	84	10	7	3
≥10	37	8	4	6	.007
Race
White	88	12	8	6
Other	35	7	6	3	.666
Sex
Female	47	5	4	3
Male	76	14	10	6	.732
WBC (10⁹/L)
≤100	103	14	10	5
>100	20	5	4	4	.127
Lineage
T-cell	36	5	3	3
B-cell	87	14	11	6	.945
Mediastinal mass
Absent	100	16	12	8
Present	23	3	2	1	.919
DNA index
<1.16 or >1.60	96	15	13	8
1.16-1.60	27	4	1	1	.550
CNS3
No	118	19	13	9
Yes	5	0	1	0	.745
Ploidy^3-151
≤50 chromosomes	88	13	12	7
>50 chromosomes	34	5	2	1	.589
TEL gene^3-151
Germline	71	11	10	6
Rearranged	13	1	1	0	.708
Ph chromosome
No	123	17	12	5
Yes	0	2	2	4	<.001
MLL gene
Germline	115	16	13	7
Rearranged	8	3	1	2	.195

Presenting feature	MRD-negative (<0.01%)	MRD-positive			P value^3-150
Presenting feature	MRD-negative (<0.01%)	≥0.01%<0.1%	≥0.1%<1%	≥1%	P value^3-150
Age (y)
<1	2	1	3	0
1-9	84	10	7	3
≥10	37	8	4	6	.007
Race
White	88	12	8	6
Other	35	7	6	3	.666
Sex
Female	47	5	4	3
Male	76	14	10	6	.732
WBC (10⁹/L)
≤100	103	14	10	5
>100	20	5	4	4	.127
Lineage
T-cell	36	5	3	3
B-cell	87	14	11	6	.945
Mediastinal mass
Absent	100	16	12	8
Present	23	3	2	1	.919
DNA index
<1.16 or >1.60	96	15	13	8
1.16-1.60	27	4	1	1	.550
CNS3
No	118	19	13	9
Yes	5	0	1	0	.745
Ploidy^3-151
≤50 chromosomes	88	13	12	7
>50 chromosomes	34	5	2	1	.589
TEL gene^3-151
Germline	71	11	10	6
Rearranged	13	1	1	0	.708
Ph chromosome
No	123	17	12	5
Yes	0	2	2	4	<.001
MLL gene
Germline	115	16	13	7
Rearranged	8	3	1	2	.195

MRD, minimal residual disease; WBC, white blood cell; CNS, central nervous system; Ph, Philadelphia.

By exact chi-square test for independence.

Data not available in all cases.