IC60 concentrations of antileukemic agents alone and in combination with STI571
| Agent(s) . | MO7 . | MO7p210 . | K562 . |
|---|---|---|---|
| STI571 | >10 μmol/L | 0.07 μmol/L | 0.27 μmol/L |
| HU | 63 μmol/L | 167 μmol/L | 367 μmol/L |
| STI571 + HU | 59 μmol/L | 110 μmol/L | 340 μmol/L |
| DNR | 59 nmol/L | 154 nmol/L | 164 nmol/L |
| STI571 + DNR | 57 nmol/L | 47 nmol/L | 72 nmol/L |
| IFN | 7.6e5 IU/mL | 7.2e5 IU/mL | 6.0e5 IU/mL |
| STI571 + IFN | 7.3e5 IU/mL | 1.5e5 IU/mL | 3.2e5 IU/mL |
| Ara-C | 45 nmol/L | 218 nmol/L | 159 nmol/L |
| STI571 + Ara-C | 40 nmol/L | 42 nmol/L | 53 nmol/L |
| Agent(s) . | MO7 . | MO7p210 . | K562 . |
|---|---|---|---|
| STI571 | >10 μmol/L | 0.07 μmol/L | 0.27 μmol/L |
| HU | 63 μmol/L | 167 μmol/L | 367 μmol/L |
| STI571 + HU | 59 μmol/L | 110 μmol/L | 340 μmol/L |
| DNR | 59 nmol/L | 154 nmol/L | 164 nmol/L |
| STI571 + DNR | 57 nmol/L | 47 nmol/L | 72 nmol/L |
| IFN | 7.6e5 IU/mL | 7.2e5 IU/mL | 6.0e5 IU/mL |
| STI571 + IFN | 7.3e5 IU/mL | 1.5e5 IU/mL | 3.2e5 IU/mL |
| Ara-C | 45 nmol/L | 218 nmol/L | 159 nmol/L |
| STI571 + Ara-C | 40 nmol/L | 42 nmol/L | 53 nmol/L |
IC60 concentrations were determined as described in Figure 1.
HU indicates hydroxyurea; DNR, daunorubicin; IFN, interferon; Ara-C, cytosine arabinoside.