Parameter values in studies of kinetics of murine and feline HSCs
| Parameter . | Murine . | Feline best value . | |
|---|---|---|---|
| Acceptable range . | Best fit . | ||
| HSC replication rate (λ) | 1 per 1.8-6.6 wk | 1 per 2.5 wk | 1 per 8.3-10 wk |
| HSC differentiation rate (ν) | 1 per 1.9-13 wk | 1 per 3.4 wk | 1 per 12.5 wk |
| HSC apoptosis rate (α) | 0-1 per 2.0 wk | 1 per 20 wk | 0-1 per 50 wk |
| HSC frequency in nucleated marrow cells | 4-22/105 | 8/105 | 6/107 |
| Parameter . | Murine . | Feline best value . | |
|---|---|---|---|
| Acceptable range . | Best fit . | ||
| HSC replication rate (λ) | 1 per 1.8-6.6 wk | 1 per 2.5 wk | 1 per 8.3-10 wk |
| HSC differentiation rate (ν) | 1 per 1.9-13 wk | 1 per 3.4 wk | 1 per 12.5 wk |
| HSC apoptosis rate (α) | 0-1 per 2.0 wk | 1 per 20 wk | 0-1 per 50 wk |
| HSC frequency in nucleated marrow cells | 4-22/105 | 8/105 | 6/107 |
If the ratio R0:C0is arbitrarily decreased to 1:4, a murine HSC frequency of 4/105 nucleated marrow cells also leads to simulated results that satisfy the criteria for best fit. The acceptable range for μ, the average rate of extinction of a differentiating clone, is 1 per 0.4 to 29 weeks, and the best-fit value is 1 per 6.9 weeks. Values for feline HSCs are from Abkowitz et al.1