Prognostic evaluation of various clinical and laboratory parameters in 114 patients with myelofibrosis with myeloid metaplasia
| Parameter . | Effect on survival from time of diagnosis (P) . |
|---|---|
| Bone marrow angiogenesis | < .01 |
| Sex | .20 |
| Age | < .01 |
| Bone marrow cytogenetics (normal vs abnormal) | .27 |
| Bone marrow cellularity | .45 |
| Degree of reticulin fibrosis | .50 |
| Degree of osteosclerosis | .25 |
| Megakaryocyte clumping | .95 |
| Dupriez score | .88 |
| Hemoglobin level | .13 |
| White blood cell count | .61 |
| Platelet count | .84 |
| Circulating blast percentage | .02 |
| Red cell transfusion dependency | .41 |
| Spleen size | .16 |
| Liver size | .24 |
| History of weight loss | .76 |
| Parameter . | Effect on survival from time of diagnosis (P) . |
|---|---|
| Bone marrow angiogenesis | < .01 |
| Sex | .20 |
| Age | < .01 |
| Bone marrow cytogenetics (normal vs abnormal) | .27 |
| Bone marrow cellularity | .45 |
| Degree of reticulin fibrosis | .50 |
| Degree of osteosclerosis | .25 |
| Megakaryocyte clumping | .95 |
| Dupriez score | .88 |
| Hemoglobin level | .13 |
| White blood cell count | .61 |
| Platelet count | .84 |
| Circulating blast percentage | .02 |
| Red cell transfusion dependency | .41 |
| Spleen size | .16 |
| Liver size | .24 |
| History of weight loss | .76 |
Values in boldface indicate parameters that were identified by both univariate and multivariate analyses as risk factors for overall survival.