Correlation between homozygous deletions and loss of HLA class II expression
| . | HLA-DQ expression (n = 22) . | HLA-DR expression (n = 25) . | ||
|---|---|---|---|---|
| + . | − . | + . | − . | |
| No deletion | 6 | 7 | 8 | 6 |
| Homozygous deletion | 0 | 9 | 1 | 10 |
| . | HLA-DQ expression (n = 22) . | HLA-DR expression (n = 25) . | ||
|---|---|---|---|---|
| + . | − . | + . | − . | |
| No deletion | 6 | 7 | 8 | 6 |
| Homozygous deletion | 0 | 9 | 1 | 10 |
For correlation analysis of loss of HLA-DQ expression, homozygous deletions of PAC 93N13 covering the only functional HLA-DQA gene DQA1 were taken into account (differences significant as determined by the chi-square test; P < .01); similarly, for HLA-DR expression PAC 172K2, covering the only HLA-DRA gene was used (P < .01). HLA indicates human leukocyte antigen.