Distribution of mutations in VH genes of HCV-associated NHLs
| Patient no. . | VH family∖gene . | R/S mutation ratio in FRs . | R/S mutation ratio in CDRs . | ||||
|---|---|---|---|---|---|---|---|
| Observed (R:S) . | Expected . | P . | Observed (R:S) . | Expected . | P . | ||
| 1 | VH1∖DP-88 | 4.000 (4:1) | 3.297 | .04387 | ∞ (3:0) | 3.028 | .19795 |
| 2 | VH1∖DP-88 | 0.833 (5:6) | 3.297 | .00020 | 0.750 (3:4) | 3.028 | .21336 |
| 3 | VH1∖DP-10 | 1.000 (5:5) | 3.306 | .00074 | 2.000 (4:2) | 3.028 | .20844 |
| 4 | VH3∖DP-47 | 0.667 (2:3) | 3.264 | .00764 | 0.500 (1:2) | 3.792 | .36656 |
| 5 | VH3∖DP-54 | 0.666 (4:6) | 3.264 | .00433 | ∞ (2:0) | 5.091 | .23696 |
| 6 | VH3∖DP-54 | 0.400 (2:5) | 3.226 | .00061 | 1.500 (3:2) | 5.091 | .24162 |
| 7 | VH4∖DP-71 | ∞ (1:0) | 3.000 | 0.29193 | ∞ (1:0) | 3.704 | .34102 |
| 8 | VH3∖DP-51 | 3.000 (6:2) | 3.265 | .00160 | 3.000 (6:2) | 4.875 | .10878 |
| 9 | VH1∖DP-75 | 4.000 (4:1) | 3.686 | 0.10068 | ∞ (1:0) | 3.152 | .31985 |
| 10 | VH3∖DP-54 | 1.154 (15:13) | 3.198 | 9.81 × 10−7 | 5.000 (5:1) | 5.091 | .16141 |
| 11 | VH3∖DP-47 | 2.400 (12:5) | 3.548 | .000204 | ∞ (10:0) | 3.230 | .06237 |
| 12 | VH4∖DP-71 | 1.200 (6:5) | 2.870 | .01760 | ∞ (4:0) | 3.310 | .19803 |
| 13 | VH4∖DP-63 | 1.143 (8:7) | 3.129 | .00333 | ∞ (2:0) | 3.483 | .13081 |
| 14 | VH3∖DP-49 | 1.000 (7:7) | 3.171 | .00202 | ∞ (3:0) | 4.000 | .19038 |
| 15 | VH3∖DP-54 | ∞ (4:0) | 3.226 | .07310 | ∞ (3:0) | 5.091 | .20099 |
| 16 | VH1∖DP-8 | 0.600 (3:5) | 3.713 | .01920 | 0.000 (0:0) | 3.152 | .13103 |
| 17 | VH3∖DP-51 | 1.000 (1:1) | 3.265 | .29014 | 0.000 (0:0) | 4.875 | .54760 |
| Patient no. . | VH family∖gene . | R/S mutation ratio in FRs . | R/S mutation ratio in CDRs . | ||||
|---|---|---|---|---|---|---|---|
| Observed (R:S) . | Expected . | P . | Observed (R:S) . | Expected . | P . | ||
| 1 | VH1∖DP-88 | 4.000 (4:1) | 3.297 | .04387 | ∞ (3:0) | 3.028 | .19795 |
| 2 | VH1∖DP-88 | 0.833 (5:6) | 3.297 | .00020 | 0.750 (3:4) | 3.028 | .21336 |
| 3 | VH1∖DP-10 | 1.000 (5:5) | 3.306 | .00074 | 2.000 (4:2) | 3.028 | .20844 |
| 4 | VH3∖DP-47 | 0.667 (2:3) | 3.264 | .00764 | 0.500 (1:2) | 3.792 | .36656 |
| 5 | VH3∖DP-54 | 0.666 (4:6) | 3.264 | .00433 | ∞ (2:0) | 5.091 | .23696 |
| 6 | VH3∖DP-54 | 0.400 (2:5) | 3.226 | .00061 | 1.500 (3:2) | 5.091 | .24162 |
| 7 | VH4∖DP-71 | ∞ (1:0) | 3.000 | 0.29193 | ∞ (1:0) | 3.704 | .34102 |
| 8 | VH3∖DP-51 | 3.000 (6:2) | 3.265 | .00160 | 3.000 (6:2) | 4.875 | .10878 |
| 9 | VH1∖DP-75 | 4.000 (4:1) | 3.686 | 0.10068 | ∞ (1:0) | 3.152 | .31985 |
| 10 | VH3∖DP-54 | 1.154 (15:13) | 3.198 | 9.81 × 10−7 | 5.000 (5:1) | 5.091 | .16141 |
| 11 | VH3∖DP-47 | 2.400 (12:5) | 3.548 | .000204 | ∞ (10:0) | 3.230 | .06237 |
| 12 | VH4∖DP-71 | 1.200 (6:5) | 2.870 | .01760 | ∞ (4:0) | 3.310 | .19803 |
| 13 | VH4∖DP-63 | 1.143 (8:7) | 3.129 | .00333 | ∞ (2:0) | 3.483 | .13081 |
| 14 | VH3∖DP-49 | 1.000 (7:7) | 3.171 | .00202 | ∞ (3:0) | 4.000 | .19038 |
| 15 | VH3∖DP-54 | ∞ (4:0) | 3.226 | .07310 | ∞ (3:0) | 5.091 | .20099 |
| 16 | VH1∖DP-8 | 0.600 (3:5) | 3.713 | .01920 | 0.000 (0:0) | 3.152 | .13103 |
| 17 | VH3∖DP-51 | 1.000 (1:1) | 3.265 | .29014 | 0.000 (0:0) | 4.875 | .54760 |
P indicates probability that the observed R mutations occurred by chance; the value is reported in bold when statistically significant (P = .05).