Distribution of mutations in VK genes of HCV-associated NHLs
| Patient no. . | VK family∖gene . | R/S mutation ratio in FRs . | R/S mutation ration in CDRs . | ||||
|---|---|---|---|---|---|---|---|
| Observed (R:S) . | Expected . | P . | Observed (R:S) . | Expected . | P . | ||
| 1 | VKIII∖humkv325 | 0.500 (1:2) | 3.407 | .01942 | ∞ (2:0) | 3.833 | .13270 |
| 2 | VKIII∖humkv325 | 0.428 (3:7) | 3.404 | .00030 | 0.000 (0:1) | 3.647 | .16295 |
| 3 | VKIII∖humkv325 | 6.000 (6:1) | 3.404 | .08305 | 0.000 (0:0) | 3.833 | .17392 |
| 4 | VKIII∖humkv325 | 2.000 (2:1) | 3.370 | .04108 | ∞ (2:0) | 3.833 | .14776 |
| 5 | VKIII∖humkv328 | 0.500 (2:4) | 3.280 | .00995 | 0.000 (0:0) | 3.091 | .58344 |
| 7 | VKIII∖humkv325 | 0.500 (1:2) | 3.407 | .01942 | 1.000 (1:1) | 3.833 | .38194 |
| 10 | VKIII∖humkv328 | 0.900 (9:10) | 3.288 | .00000118 | 6.000 (6:1) | 3.706 | .09955 |
| 11 | VKI∖L12a | 2.666 (8:3) | 3.264 | .00474 | ∞ (2:0) | 4.923 | .28112 |
| 12 | VKIII∖humkv325 | 2.000 (4:2) | 3.370 | .03242 | ∞ (1:0) | 3.833 | .37445 |
| 13 | VKI∖A30 | 1.500 (3:2) | 3.292 | .01618 | ∞ (2:0) | 3.158 | .19169 |
| 14 | VKIII∖humkv328 | 0.750 (3:4) | 3.294 | .007609 | ∞ (1:0) | 3.706 | .38134 |
| 16 | VKIII∖humkv325 | 1.000 (4:4) | 3.405 | .00808 | ∞ (1:0) | 3.833 | .34521 |
| Patient no. . | VK family∖gene . | R/S mutation ratio in FRs . | R/S mutation ration in CDRs . | ||||
|---|---|---|---|---|---|---|---|
| Observed (R:S) . | Expected . | P . | Observed (R:S) . | Expected . | P . | ||
| 1 | VKIII∖humkv325 | 0.500 (1:2) | 3.407 | .01942 | ∞ (2:0) | 3.833 | .13270 |
| 2 | VKIII∖humkv325 | 0.428 (3:7) | 3.404 | .00030 | 0.000 (0:1) | 3.647 | .16295 |
| 3 | VKIII∖humkv325 | 6.000 (6:1) | 3.404 | .08305 | 0.000 (0:0) | 3.833 | .17392 |
| 4 | VKIII∖humkv325 | 2.000 (2:1) | 3.370 | .04108 | ∞ (2:0) | 3.833 | .14776 |
| 5 | VKIII∖humkv328 | 0.500 (2:4) | 3.280 | .00995 | 0.000 (0:0) | 3.091 | .58344 |
| 7 | VKIII∖humkv325 | 0.500 (1:2) | 3.407 | .01942 | 1.000 (1:1) | 3.833 | .38194 |
| 10 | VKIII∖humkv328 | 0.900 (9:10) | 3.288 | .00000118 | 6.000 (6:1) | 3.706 | .09955 |
| 11 | VKI∖L12a | 2.666 (8:3) | 3.264 | .00474 | ∞ (2:0) | 4.923 | .28112 |
| 12 | VKIII∖humkv325 | 2.000 (4:2) | 3.370 | .03242 | ∞ (1:0) | 3.833 | .37445 |
| 13 | VKI∖A30 | 1.500 (3:2) | 3.292 | .01618 | ∞ (2:0) | 3.158 | .19169 |
| 14 | VKIII∖humkv328 | 0.750 (3:4) | 3.294 | .007609 | ∞ (1:0) | 3.706 | .38134 |
| 16 | VKIII∖humkv325 | 1.000 (4:4) | 3.405 | .00808 | ∞ (1:0) | 3.833 | .34521 |
P indicates the probability that the observed R mutations occurred by chance; the value is reported in bold when statistically significant (P = .05).