Molecular events associated with progression of Friend virus-induced erythroleukemia
| Gene . | Origin of cell line or tumor . | Genetic change . | Frequency . | References . |
|---|---|---|---|---|
| PU.1(Sfpi1) | FVP/FVA | Proviral insertion, ↑Pu.1 | 70%-95% | 15, 16 |
| Fli1 | F-MuLV | Proviral insertion, ↑Fli-1 | 75%-90% | 97, 98 |
| Fli2(Nfe2) | FVP, F-MuLV | Proviral insertion, ↓Nfe2 | 10% | 101 |
| Epo | F-MuLV | Genomic rearrangement, ↑Epo | 80% | 100 |
| EpoR | FVP | Proviral insertion, ↑EpoR | Unknown | 46, 47 |
| p53(Trp53) | FVP/FVA, F-MuLV | 1. Proviral insertion, ↓p53 | ∼ 100% | 12-14 |
| 2. Genomic rearrangement, ↓p53, truncation of p53 | ||||
| 3. Point mutation, loss of normal p53 function |
| Gene . | Origin of cell line or tumor . | Genetic change . | Frequency . | References . |
|---|---|---|---|---|
| PU.1(Sfpi1) | FVP/FVA | Proviral insertion, ↑Pu.1 | 70%-95% | 15, 16 |
| Fli1 | F-MuLV | Proviral insertion, ↑Fli-1 | 75%-90% | 97, 98 |
| Fli2(Nfe2) | FVP, F-MuLV | Proviral insertion, ↓Nfe2 | 10% | 101 |
| Epo | F-MuLV | Genomic rearrangement, ↑Epo | 80% | 100 |
| EpoR | FVP | Proviral insertion, ↑EpoR | Unknown | 46, 47 |
| p53(Trp53) | FVP/FVA, F-MuLV | 1. Proviral insertion, ↓p53 | ∼ 100% | 12-14 |
| 2. Genomic rearrangement, ↓p53, truncation of p53 | ||||
| 3. Point mutation, loss of normal p53 function |