| CXB-12 BMC injected in each recipient | 5 × 104 |
| CByB6F1 BMC injected in each recipient | 5 × 105 |
| No. recipients injected | 38 |
| No. recipients available at 6 months | 37 |
| No. recipients with 0% donor type blood cell at 6 months | 11 |
| No. HSCs in 5 × 104 CXB-12 BMCs | 1.2 |
| P0 = 11/37 = 0.2973; N = −lnP0 = −ln 0.2973 = 1.2 | |
| No. HSCs in 105 CXB-12 BMCs | 2.4 |
| No. HSCs in 5 × 105CByB6F1 BMCs (assumed)3-150 | 5 |
| Repopulating potential per CByB6F1 HSC (defined) | 1 |
| Repopulating potential per CXB-12 HSC relative to CByB6F1 standard | 1.4 |
| CXB-12 BMC injected in each recipient | 5 × 104 |
| CByB6F1 BMC injected in each recipient | 5 × 105 |
| No. recipients injected | 38 |
| No. recipients available at 6 months | 37 |
| No. recipients with 0% donor type blood cell at 6 months | 11 |
| No. HSCs in 5 × 104 CXB-12 BMCs | 1.2 |
| P0 = 11/37 = 0.2973; N = −lnP0 = −ln 0.2973 = 1.2 | |
| No. HSCs in 105 CXB-12 BMCs | 2.4 |
| No. HSCs in 5 × 105CByB6F1 BMCs (assumed)3-150 | 5 |
| Repopulating potential per CByB6F1 HSC (defined) | 1 |
| Repopulating potential per CXB-12 HSC relative to CByB6F1 standard | 1.4 |
BMC indicates bone marrow cell; HSC, hematopoietic stem cell.
Recipients are 2- to 4-month-old, natural killer cell–depleted, lethally irradiated, male CByB6F1 mice. BMCs were pooled from 3 young (2- to 3-month-old) CXB-12 males (Gpi1a/Gpi1a) and competed with BMCs pooled from 3 young CByB6F1 males (Gpi1b/Gpi1b).
For CByB6F1 competitors, HSC concentration is taken as 1 per 105 BMCs; repopulating ability per HSC is defined as 1.