Major immunological data since 1995
| . | Dec 1995 . | Nov 1996 . | Feb 1997 . | Mar 1998 . | Feb 1999 . | Jan 2000 . |
|---|---|---|---|---|---|---|
| Lymphocytes* | 1100 | 838 | 970 | 1014 | 1090 | 1215 |
| CD cells† | ||||||
| CD4 | 47 (39-56) | 42 (36-56) | 48 (36-56) | 44 (36-56) | 47 (36-56) | 50 (36-56) |
| CD4+CD45R0+ | 41 (15-29) | 39 (10-27) | 47 (10-27) | 42 (10-27) | 40 (10-27) | 47 (10-27) |
| CD4+CD45RA+ | 3 (13-35) | 6 (10-35) | 3 (10-35) | 3 (10-35) | 3 (10-35) | 3 (10-35) |
| CD8 | 9 (15-27) | 5 (13-31) | 9 (13-31) | 7 (13-31) | 4 (13-31) | 7 (13-31) |
| Total immunoglobulin‡ | ||||||
| IgG‡ | 609 (697-1593) | — | 594 (697-1593) | 609 (697-1593) | 671 (644-1436) | 688 (644-1436) |
| IgG2 | 90 (140-440) | — | 147 (95-468) | 142 (95-468) | 148 (95-468) | 146 (95-468) |
| IgM | 39 (39-330) | — | 37 (39-330) | 38 (39-330) | 39 (55-206) | 40 (55-206) |
| . | Dec 1995 . | Nov 1996 . | Feb 1997 . | Mar 1998 . | Feb 1999 . | Jan 2000 . |
|---|---|---|---|---|---|---|
| Lymphocytes* | 1100 | 838 | 970 | 1014 | 1090 | 1215 |
| CD cells† | ||||||
| CD4 | 47 (39-56) | 42 (36-56) | 48 (36-56) | 44 (36-56) | 47 (36-56) | 50 (36-56) |
| CD4+CD45R0+ | 41 (15-29) | 39 (10-27) | 47 (10-27) | 42 (10-27) | 40 (10-27) | 47 (10-27) |
| CD4+CD45RA+ | 3 (13-35) | 6 (10-35) | 3 (10-35) | 3 (10-35) | 3 (10-35) | 3 (10-35) |
| CD8 | 9 (15-27) | 5 (13-31) | 9 (13-31) | 7 (13-31) | 4 (13-31) | 7 (13-31) |
| Total immunoglobulin‡ | ||||||
| IgG‡ | 609 (697-1593) | — | 594 (697-1593) | 609 (697-1593) | 671 (644-1436) | 688 (644-1436) |
| IgG2 | 90 (140-440) | — | 147 (95-468) | 142 (95-468) | 148 (95-468) | 146 (95-468) |
| IgM | 39 (39-330) | — | 37 (39-330) | 38 (39-330) | 39 (55-206) | 40 (55-206) |
Previous data have been published elsewhere.9Phenotype and T-cell activation results (using mitogens and antigens) are at present similar to those reported before.9 —indicates data not determined.
Lymphocytes are expressed in number per microliter.
Each CD cell entry is expressed in percentage of positive cells (range of normal values for aged-matched controls in brackets). A severe decrease in the number and function of CD4+CD45RA+ and cytotoxic (CD8+) lymphocytes is maintained, whereas CD4+CD45R0+, B, and NK lymphocytes are unaffected.9 These data allow us to propose a model where CD4 or CD8 molecules interact with the TCR/CD3 complex during antigen recognition through the CD3δ or the CD3γ protein of the complex, respectively.3 This also correlates with previously obtained data suggesting that αβδεζ complexes are biochemically stable (albeit epitopically altered) and may reach the cell surface in certain circumstances.4
Immunoglobulins expressed in mg/dL (range of normal values for aged-matched controls in brackets). IgG1, IgG3, IgG4, and IgA levels are always into normal ranges.