Table 1. Morphologic subforms of ALCL... | American Society of Hematology

Table 1.

Morphologic subforms of ALCL and their correlation with immunophenotype

Histologic subform	CD30	Immunophenotype	EMA⁺cases	ALK⁺ cases (%)
Common (classic) type^* 3,10 13	Positive	Most T/null	Majority	60-90
Giant cell-rich3,10 13	Positive	Most T/null	Minority	30-40
Small cell11 13	Positive (mainly large cells)	T	Most^†	100
Lymphohistiocytic3,8,10 13	Positive	T	Most^†	80-100
Hodgkin-like3,10,13 65	Positive	Null (rarely T)	Minority	∼ 15
Rare subforms
Sarcomatoid⁴²	Positive	NDA	NDA	NDA
Neutrophil rich13,44 45
Eosinophil rich⁴³
Signet ring15 46

Histologic subform	CD30	Immunophenotype	EMA⁺cases	ALK⁺ cases (%)
Common (classic) type^* 3,10 13	Positive	Most T/null	Majority	60-90
Giant cell-rich3,10 13	Positive	Most T/null	Minority	30-40
Small cell11 13	Positive (mainly large cells)	T	Most^†	100
Lymphohistiocytic3,8,10 13	Positive	T	Most^†	80-100
Hodgkin-like3,10,13 65	Positive	Null (rarely T)	Minority	∼ 15
Rare subforms
Sarcomatoid⁴²	Positive	NDA	NDA	NDA
Neutrophil rich13,44 45
Eosinophil rich⁴³
Signet ring15 46

The most relevant subforms described are indicated in bold. NDA indicates no data available.

The monomorphic subform represents a variant of the common type.

Usually detectable on the larger cells.