CD30+ large cell lymphomas with anaplastic morphology: immunophenotype, antigen-receptor genotype, and EBV infection
| Immunophenotype . | Incidence . | Clonal rearrangements . | EBV . | Cytotoxic molecules . | Chimeric ALK* . | |
|---|---|---|---|---|---|---|
| TCRγ/β . | IgH . | |||||
| T null | 55% to 76%1,6,52,53 58 | + (90%) | − | − | +/− | + (53% to 89%)40,66 69 |
| 6% to 25%36 40 | + (90%) | − | − | +/− | ||
| B | 5% to 21%1,36,52 59 | − | +/− | +/− | − | −† |
| Immunophenotype . | Incidence . | Clonal rearrangements . | EBV . | Cytotoxic molecules . | Chimeric ALK* . | |
|---|---|---|---|---|---|---|
| TCRγ/β . | IgH . | |||||
| T null | 55% to 76%1,6,52,53 58 | + (90%) | − | − | +/− | + (53% to 89%)40,66 69 |
| 6% to 25%36 40 | + (90%) | − | − | +/− | ||
| B | 5% to 21%1,36,52 59 | − | +/− | +/− | − | −† |
Refers to systemic ALCL. + indicates all cases positive; +/−, majority of cases positive; −/+, minority of cases positive; and −, all cases negative.
Gascoyne et al101 reported about 5 positive cases; however, in other studies,66 69 the expression of ALK fusion proteins was not observed even though a large number of diffuse large B-cell lymphoma cases was investigated.