Table 3. Correlation between clinical... | American Society of Hematology

Table 3.

Correlation between clinical features, morphology, and immunophenotype in ALCL

Clinical form of ALCL	Morphology	Phenotype	EMA	Chimeric ALK
Systemic	All variants	Mostly T/null	Frequently positive	Positive (∼ 60%)
Primary cutaneous	Common type to lymphomatoid papulosis	T/null	Some	Negative^3-150
HIV-related	Common or giant cell–rich	Mostly B	NDA	NDA
		Rarely T/null	NDA	NDA
Secondary	Variable	T/null^3-151	Negative	Negative

Clinical form of ALCL	Morphology	Phenotype	EMA	Chimeric ALK
Systemic	All variants	Mostly T/null	Frequently positive	Positive (∼ 60%)
Primary cutaneous	Common type to lymphomatoid papulosis	T/null	Some	Negative^3-150
HIV-related	Common or giant cell–rich	Mostly B	NDA	NDA
		Rarely T/null	NDA	NDA
Secondary	Variable	T/null^3-151	Negative	Negative

NDA indicates no data available.

Rare cases reported to be ALK⁺ probably represent systemic ALCL with skin involvement, in which the extracutaneous disease escaped recognition.

Immunophenotype depends on the preceding lymphoma disease.