Survival at 8 years actuarial in CCG-2891, comparing the 3 postremission arms for various risk factors
| Risk factor . | Allogeneic BMT . | Pvalue (allo vs auto) . | Autologous BMT . | Pvalue (auto vs chemo) . | Chemotherapy . | Pvalue (chemo vs allo) . | |||
|---|---|---|---|---|---|---|---|---|---|
| No. . | Survival, % . | No. . | Survival, % . | No. . | Survival, % . | ||||
| Age, y | |||||||||
| 0-1 | 24 | 71 | .03 | 43 | 40 | .009 | 49 | 61 | .60 |
| 3-10 | 78 | 56 | .07 | 68 | 49 | .34 | 62 | 55 | .46 |
| 11-20 | 79 | 61 | .17 | 66 | 51 | .43 | 68 | 45 | .03 |
| White blood count at diagnosis (SI units) | |||||||||
| < 20 | 96 | 66 | .08 | 81 | 54 | .59 | 83 | 58 | .22 |
| 20-100 | 67 | 49 | .05 | 66 | 42 | .36 | 63 | 48 | .30 |
| > 100 | 18 | 63 | .10 | 30 | 43 | .38 | 33 | 49 | .28 |
| FAB | |||||||||
| M0 | 6 | 40 | .21 | 4 | 100 | .05 | 5 | 20 | .03 |
| M1 | 28 | 42 | .62 | 25 | 47 | .44 | 31 | 61 | .66 |
| M2 | 45 | 66 | .34 | 51 | 52 | .79 | 44 | 57 | .47 |
| M3 | 10 | 68 | .51 | 9 | 44 | .65 | 11 | 55 | .65 |
| M4 | 45 | 62 | .003 | 42 | 38 | .07 | 39 | 53 | .24 |
| M5 | 22 | 68 | .07 | 28 | 50 | .44 | 31 | 58 | .21 |
| M6 | 6 | 50 | .43 | 1 | 100 | .30 | 4 | 25 | .31 |
| M7 | 10 | 58 | .33 | 11 | 36 | .91 | 5 | 40 | .56 |
| Cytogenetics | |||||||||
| Normal | 15 | 67 | .24 | 18 | 44 | .49 | 17 | 47 | .44 |
| 11q23 abnormality | 11 | 68 | .42 | 12 | 58 | .40 | 19 | 47 | .15 |
| t(8;21) | 15 | 47 | .73 | 12 | 42 | .23 | 5 | 80 | .30 |
| t(15;17) | 6 | 67 | .31 | 4 | 25 | .59 | 6 | 25 | .35 |
| Inv(16q) abnormality | 9 | 78 | .04 | 7 | 29 | .05 | 7 | 71 | .89 |
| Da AB +8 | 2 | 0 | .05 | 4 | 75 | .48 | 2 | 100 | .16 |
| -7/7q- | 3 | 67 | — | 0 | — | — | 2 | 50 | .59 |
| Other | 18 | — | — | 26 | — | — | 19 | — | — |
| Risk factor . | Allogeneic BMT . | Pvalue (allo vs auto) . | Autologous BMT . | Pvalue (auto vs chemo) . | Chemotherapy . | Pvalue (chemo vs allo) . | |||
|---|---|---|---|---|---|---|---|---|---|
| No. . | Survival, % . | No. . | Survival, % . | No. . | Survival, % . | ||||
| Age, y | |||||||||
| 0-1 | 24 | 71 | .03 | 43 | 40 | .009 | 49 | 61 | .60 |
| 3-10 | 78 | 56 | .07 | 68 | 49 | .34 | 62 | 55 | .46 |
| 11-20 | 79 | 61 | .17 | 66 | 51 | .43 | 68 | 45 | .03 |
| White blood count at diagnosis (SI units) | |||||||||
| < 20 | 96 | 66 | .08 | 81 | 54 | .59 | 83 | 58 | .22 |
| 20-100 | 67 | 49 | .05 | 66 | 42 | .36 | 63 | 48 | .30 |
| > 100 | 18 | 63 | .10 | 30 | 43 | .38 | 33 | 49 | .28 |
| FAB | |||||||||
| M0 | 6 | 40 | .21 | 4 | 100 | .05 | 5 | 20 | .03 |
| M1 | 28 | 42 | .62 | 25 | 47 | .44 | 31 | 61 | .66 |
| M2 | 45 | 66 | .34 | 51 | 52 | .79 | 44 | 57 | .47 |
| M3 | 10 | 68 | .51 | 9 | 44 | .65 | 11 | 55 | .65 |
| M4 | 45 | 62 | .003 | 42 | 38 | .07 | 39 | 53 | .24 |
| M5 | 22 | 68 | .07 | 28 | 50 | .44 | 31 | 58 | .21 |
| M6 | 6 | 50 | .43 | 1 | 100 | .30 | 4 | 25 | .31 |
| M7 | 10 | 58 | .33 | 11 | 36 | .91 | 5 | 40 | .56 |
| Cytogenetics | |||||||||
| Normal | 15 | 67 | .24 | 18 | 44 | .49 | 17 | 47 | .44 |
| 11q23 abnormality | 11 | 68 | .42 | 12 | 58 | .40 | 19 | 47 | .15 |
| t(8;21) | 15 | 47 | .73 | 12 | 42 | .23 | 5 | 80 | .30 |
| t(15;17) | 6 | 67 | .31 | 4 | 25 | .59 | 6 | 25 | .35 |
| Inv(16q) abnormality | 9 | 78 | .04 | 7 | 29 | .05 | 7 | 71 | .89 |
| Da AB +8 | 2 | 0 | .05 | 4 | 75 | .48 | 2 | 100 | .16 |
| -7/7q- | 3 | 67 | — | 0 | — | — | 2 | 50 | .59 |
| Other | 18 | — | — | 26 | — | — | 19 | — | — |