Table 1. Factor VIII levels in plasma... | American Society of Hematology

Table 1.

Factor VIII levels in plasma and characterization of anti–factor VIII autoantibodies in 3 patients with acquired hemophilia A

Patient	Plasma level			Inhibitor neutralization by FVIII domain, %					Inhibition of IgG binding to FVIII, %
Patient	FVII:C (U/dL)	FVII:Ag (U/dL)	Anti-FVII:C (BU/mL)	80-kd LCh	72-kd LCh	HCh	C2	A2	80-kd LCh	72-kd LCh	HCh	C2	A2
1	4.1	101	4.9	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5
2	4.3	98	3.5	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5
3	3.6	87	5.3	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5

Patient	Plasma level			Inhibitor neutralization by FVIII domain, %					Inhibition of IgG binding to FVIII, %
Patient	FVII:C (U/dL)	FVII:Ag (U/dL)	Anti-FVII:C (BU/mL)	80-kd LCh	72-kd LCh	HCh	C2	A2	80-kd LCh	72-kd LCh	HCh	C2	A2
1	4.1	101	4.9	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5
2	4.3	98	3.5	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5
3	3.6	87	5.3	> 95	> 95	< 5	< 5	< 5	> 95	> 95	< 5	< 5	< 5

FVIII indicates factor VIII; FVIII:C, FVIII activity; FVIII:Ag, FVIII antigen; BU, Bethesda unit; LCh, light chain; HCh, heavy chain.