Prevalence of single prothrombotic defects in childhood venous thrombosis in relation to recurrence status
| Single prothrombotic defects (n = 176) . | Prevalence n (%) in all patients (n = 301) . | Prevalence n (%) in patients without recurrent VTE (n = 237) . | Prevalence n (%) in patients with recurrent VTE (n = 64) . | Prevalence (%) of recurrent VTE in carriers . |
|---|---|---|---|---|
| FV 1691GA | 88 (29.2) | 71 (30.0) | 17 (26.5) | 17/88 (19.3) |
| Elevated Lp(a) | 48 (14.9) | 42 (17.7) | 6 (9.4) | 6/48 (12.5) |
| PT 20210GA | 11 (3.7) | 9 (3.8) | 2 (3.1) | 2/11 (18.2) |
| Protein C deficiency | 20 (6.6) | 15 (6.3) | 5 (7.8) | 5/20 (25.0) |
| Protein S deficiency | 4 (1.3) | 4 (1.7) | — | — |
| Antithrombin deficiency | 5 (1.7) | 4 (1.7) | 1 (1.6) | 1/5 (20.0) |
| Total | 176 (58.5) | 145 (61.2) | 31 (48.4) | 31/176 (17.6) |
| Single prothrombotic defects (n = 176) . | Prevalence n (%) in all patients (n = 301) . | Prevalence n (%) in patients without recurrent VTE (n = 237) . | Prevalence n (%) in patients with recurrent VTE (n = 64) . | Prevalence (%) of recurrent VTE in carriers . |
|---|---|---|---|---|
| FV 1691GA | 88 (29.2) | 71 (30.0) | 17 (26.5) | 17/88 (19.3) |
| Elevated Lp(a) | 48 (14.9) | 42 (17.7) | 6 (9.4) | 6/48 (12.5) |
| PT 20210GA | 11 (3.7) | 9 (3.8) | 2 (3.1) | 2/11 (18.2) |
| Protein C deficiency | 20 (6.6) | 15 (6.3) | 5 (7.8) | 5/20 (25.0) |
| Protein S deficiency | 4 (1.3) | 4 (1.7) | — | — |
| Antithrombin deficiency | 5 (1.7) | 4 (1.7) | 1 (1.6) | 1/5 (20.0) |
| Total | 176 (58.5) | 145 (61.2) | 31 (48.4) | 31/176 (17.6) |
VTE indicates venous thromboembolism; FV, factor V; Lp(a), lipoprotein (a); PT, prothrombin.