IGK and IGL gene configurations in 113 chronic B-cell leukemias (53 immunoglobulin κ+ and 60 immunoglobulin λ+) as determined by Southern blot analysis
| IGK gene configuration . | Igκ+CBL . | Igλ+ CBL . | ||||
|---|---|---|---|---|---|---|
| IGL gene configuration . | ||||||
| G/G . | G/R . | R/R . | G/G . | G/R . | R/R . | |
| G/G | — | — | — | — | — | — |
| R/G | 47% | — | — | — | — | — |
| (25/53) | ||||||
| R/R | 19% | 2% | — | — | — | — |
| (10/53) | (1/53) | |||||
| D/R | 28% | 2% | 2% | — | 10% | 1.5% |
| (15/53) | (1/53) | (1/53) | (6/60) | (1/60) | ||
| D/D | — | — | — | — | 57% | 21.5% |
| (34/60) | (13/60) | |||||
| G/D | — | — | — | — | 7% | 3% |
| (4/60) | (2/60) | |||||
| IGK gene configuration . | Igκ+CBL . | Igλ+ CBL . | ||||
|---|---|---|---|---|---|---|
| IGL gene configuration . | ||||||
| G/G . | G/R . | R/R . | G/G . | G/R . | R/R . | |
| G/G | — | — | — | — | — | — |
| R/G | 47% | — | — | — | — | — |
| (25/53) | ||||||
| R/R | 19% | 2% | — | — | — | — |
| (10/53) | (1/53) | |||||
| D/R | 28% | 2% | 2% | — | 10% | 1.5% |
| (15/53) | (1/53) | (1/53) | (6/60) | (1/60) | ||
| D/D | — | — | — | — | 57% | 21.5% |
| (34/60) | (13/60) | |||||
| G/D | — | — | — | — | 7% | 3% |
| (4/60) | (2/60) | |||||
Ig indicates immunoglobulin; G, germline configuration; R, rearranged allele; D, deletion of Jκ and/or Cκ gene segments.