Summary of data of chronic B-cell leukemia with 2 complete immunoglobulin light chain rearrangements, as identified by reverse transcriptase–polymerase chain reaction analysis and sequencing
| . | IGK/IGK . | IGK/IGL . | IGL/IGL . | Total . |
|---|---|---|---|---|
| Patients (see Tables 3-5) | 12, 14-17 | 1-36-150, 5-10 | 46-151, 20-26, 28, 29, 32 | n = 26 |
| 2 functional rearrangements | 0/6 | 5/9 | 5/11 | 10/26 |
| Somatic mutations in cases with: | ||||
| 1 functional rearrangement | 2/6 | 1/4 | 2/6 | 5/16 |
| 2 functional rearrangements | − | 3/5 | 5/5 | 8/10 |
| Both functional rearrangements transcribed | − | 4/4 | 5/5 | 9/9 |
| Double Ig light chain protein expression | − | 0/5 | Not evaluable | 0/5 |
| . | IGK/IGK . | IGK/IGL . | IGL/IGL . | Total . |
|---|---|---|---|---|
| Patients (see Tables 3-5) | 12, 14-17 | 1-36-150, 5-10 | 46-151, 20-26, 28, 29, 32 | n = 26 |
| 2 functional rearrangements | 0/6 | 5/9 | 5/11 | 10/26 |
| Somatic mutations in cases with: | ||||
| 1 functional rearrangement | 2/6 | 1/4 | 2/6 | 5/16 |
| 2 functional rearrangements | − | 3/5 | 5/5 | 8/10 |
| Both functional rearrangements transcribed | − | 4/4 | 5/5 | 9/9 |
| Double Ig light chain protein expression | − | 0/5 | Not evaluable | 0/5 |
Ig indicates immunoglobulin; CBL, chronic B-cell leukemia.
Patient 3 was classified in the IGK/IGL category, because this Igκ+ CBL contained a functional IGLrearrangement.
Patient 4 (Igλ+ CBL) was classified in theIGL/IGL category, because both IGL rearrangements were identified, but the IGK rearrangement was not found.