Table 1.

Effect of concentration gradients of Kybernin P or antithrombin III on neutrophil migration

Upper chamber
Medium10−610−3100
Kybernin P (u)     
 Lower chamber
 
   Medium 1.000  ±  0.000 1.043  ±  0.064 1.056  ±  0.082 1.092  ±  0.048* 
  10−6 1.171  ±  0.028 1.156  ±  0.034 1.124  ±  0.056 1.056  ±  0.048 
  10−3 1.400  ±  0.058† 1.184  ±  0.028 1.131  ±  0.038 1.106  ±  0.034 
  100 1.522  ±  0.044‡ 1.328  ±  0.046 1.207  ±  0.040 1.229  ±  0.030† 
AT III (u)   
 Lower chamber 
   Medium 1.000  ±  0.000 1.032  ±  0.058 0.995  ±  0.018 0.999  ±  0.068* 
  10−6 1.224  ±  0.062 1.014  ±  0.056 1.054  ±  0.064 1.063  ±  0.039 
  10−3 1.323  ±  0.088† 1.154  ±  0.068 1.009  ±  0.067 1.063  ±  0.044 
  100 1.489  ±  0.046‡ 1.281  ±  0.088 1.255  ±  0.036 1.094  ±  0.072 
Upper chamber
Medium10−610−3100
Kybernin P (u)     
 Lower chamber
 
   Medium 1.000  ±  0.000 1.043  ±  0.064 1.056  ±  0.082 1.092  ±  0.048* 
  10−6 1.171  ±  0.028 1.156  ±  0.034 1.124  ±  0.056 1.056  ±  0.048 
  10−3 1.400  ±  0.058† 1.184  ±  0.028 1.131  ±  0.038 1.106  ±  0.034 
  100 1.522  ±  0.044‡ 1.328  ±  0.046 1.207  ±  0.040 1.229  ±  0.030† 
AT III (u)   
 Lower chamber 
   Medium 1.000  ±  0.000 1.032  ±  0.058 0.995  ±  0.018 0.999  ±  0.068* 
  10−6 1.224  ±  0.062 1.014  ±  0.056 1.054  ±  0.064 1.063  ±  0.039 
  10−3 1.323  ±  0.088† 1.154  ±  0.068 1.009  ±  0.067 1.063  ±  0.044 
  100 1.489  ±  0.046‡ 1.281  ±  0.088 1.255  ±  0.036 1.094  ±  0.072 

Statistical analyses: Mann-Whitney test after Kruskal Wallis analysis of variance (P < .001); n = 5.

AT III indicates antithrombin III.

*

P < .01 vs. highest concentration of test substance exclusively in the lower chamber. Only those groups within the matrix being sufficient to distinguish between chemokinesis and chemotaxis were compared statistically by Mann-Whitney test.

†

P < .05.

‡

P < .01 vs. medium in the upper and lower chamber.

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