Table 1. Histologic, immunophenotypic,... | American Society of Hematology

Table 1.

Histologic, immunophenotypic, and PCR findings in KSHV MCD

Case no.	HIV	EBV	Diagnosis and KSHV-associated lesions	Plasmablasts	KSHV LNA	KSHV^* vIL6	Plasmablasts Ig	Fr3-JH	Fr3-Jλ
			MCD					P	P
1	−	−	Microlymphoma (Sp)	+	+	+	IgMλ	M	M
			Plasmablastic lymphoma (LN)					M	M
			MCD					P	P
2	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	P	P
			MCD					P	P
3	−	−	Microlymphoma (LN)	+	+	+	IgMλ	P	P
			MCD					P	P
4	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	M	M
			MCD					P	P
5	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	P	P
			Plasmblastic lymphoma (LN)					M	P
			MCD					P	P
6	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	P	P
			MCD					P	P
7	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	P	ND
			MCD					ND	ND
8	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	ND	ND
			MCD					P	ND
9	+	−	Microlymphoma (LN)	+	+	+	IgMλ	P	ND
10	+	−	MCD	+	+	+	IgMλ	P	ND
11	+	−	MCD	+	+	ND	IgMλ	P	P
12	+	−	MCD	+	+	+	IgMλ	P	P
13	+	−	MCD	+	+	ND	IgMλ	P	ND

Case no.	HIV	EBV	Diagnosis and KSHV-associated lesions	Plasmablasts	KSHV LNA	KSHV^* vIL6	Plasmablasts Ig	Fr3-JH	Fr3-Jλ
			MCD					P	P
1	−	−	Microlymphoma (Sp)	+	+	+	IgMλ	M	M
			Plasmablastic lymphoma (LN)					M	M
			MCD					P	P
2	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	P	P
			MCD					P	P
3	−	−	Microlymphoma (LN)	+	+	+	IgMλ	P	P
			MCD					P	P
4	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	M	M
			MCD					P	P
5	+	−	Microlymphoma (Sp)	+	+	+	IgMλ	P	P
			Plasmblastic lymphoma (LN)					M	P
			MCD					P	P
6	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	P	P
			MCD					P	P
7	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	P	ND
			MCD					ND	ND
8	+	−	Microlymphoma (Sp)	+	+	ND	IgMλ	ND	ND
			MCD					P	ND
9	+	−	Microlymphoma (LN)	+	+	+	IgMλ	P	ND
10	+	−	MCD	+	+	+	IgMλ	P	ND
11	+	−	MCD	+	+	ND	IgMλ	P	P
12	+	−	MCD	+	+	+	IgMλ	P	P
13	+	−	MCD	+	+	ND	IgMλ	P	ND

MCD indicates multicentric Castleman disease; LN, lymph node; Sp, spleen; P, polyclonal; M, monoclonal; ND, not done.

KSHV vIL-6 was expressed in 10% to 15% of KSHV-positive plasmablasts.