Effect of rhu-VEGF and VEGF neutralization (rhu-mAb-VEGF) on leukemia colony formation in advanced MDS
| UPN . | FAB type . | Immunohistochemistry . | CFU-L/105cells ± SD . | ||||
|---|---|---|---|---|---|---|---|
| VEGF . | Flt-1 . | KDR . | Control . | rhu-mAb-VEGF . | rhu-VEGF . | ||
| UAZ006 | RAEB | 0 | 0 | 0 | 25 ± 1 | 10 ± 6.6* | 140 ± 19* |
| UAZ007 | RAEB | 3 | 1 | 0 | 64 ± 24 | 34 ± 24* | 164 ± 39* |
| UAZ016 | RAEB | ND | ND | ND | 19 ± 14 | 22 ± 19 | 63 ± 31* |
| UAZ017 | RAEB | 0 | 0 | 0 | 20 ± 13 | 12 ± 7.6 | 39 ± 6.2 |
| UAZ018 | RAEB | 3 | 3 | 1 | 111 ± 57 | 106 ± 79 | 181 ± 51 |
| UAZ019 | RAEB | ND | ND | ND | 41 ± 22 | 9.3 ± 2.0* | 94 ± 71 |
| UAZ013 | RAEB-t | 4 | 3 | 3 | 182 ± 71 | 114 ± 76 | 384 ± 85* |
| UAZ020 | RAEB-t | 4 | 2 | 0 | 11.3 ± 0.5 | 0* | 21.7 ± 2* |
| UAZ021 | RAEB-t | 3 | 3 | 0 | 20 ± 5.5 | 3 ± 2.6* | 28 ± 8 |
| UAZ022 | RAEB-t | 1 | 4 | 0 | 6 ± 2 | 1.7 ± 2* | 17 ± 11* |
| UAZ023 | RAEB-t | 3 | 2 | 0 | 103 ± 23 | 63 ± 25 | 158 ± 80 |
| UAZ024 | CMML | 0 | 0 | 0 | 238 ± 8.5 | 195 ± 7.7* | 247 ± 1.1 |
| UAZ025 | CMML | 3 | 1 | 0 | 65 ± 30 | 30 ± 7.5 | 128 ± 21* |
| UAZ026 | CMML | 3 | 0 | 0 | 53 ± 23 | 52 ± 5.9 | 83 ± 12* |
| UAZ027 | CMML | 4 | 1 | 0 | 234 ± 50 | 266 ± 17 | 281 ± 24 |
| UPN . | FAB type . | Immunohistochemistry . | CFU-L/105cells ± SD . | ||||
|---|---|---|---|---|---|---|---|
| VEGF . | Flt-1 . | KDR . | Control . | rhu-mAb-VEGF . | rhu-VEGF . | ||
| UAZ006 | RAEB | 0 | 0 | 0 | 25 ± 1 | 10 ± 6.6* | 140 ± 19* |
| UAZ007 | RAEB | 3 | 1 | 0 | 64 ± 24 | 34 ± 24* | 164 ± 39* |
| UAZ016 | RAEB | ND | ND | ND | 19 ± 14 | 22 ± 19 | 63 ± 31* |
| UAZ017 | RAEB | 0 | 0 | 0 | 20 ± 13 | 12 ± 7.6 | 39 ± 6.2 |
| UAZ018 | RAEB | 3 | 3 | 1 | 111 ± 57 | 106 ± 79 | 181 ± 51 |
| UAZ019 | RAEB | ND | ND | ND | 41 ± 22 | 9.3 ± 2.0* | 94 ± 71 |
| UAZ013 | RAEB-t | 4 | 3 | 3 | 182 ± 71 | 114 ± 76 | 384 ± 85* |
| UAZ020 | RAEB-t | 4 | 2 | 0 | 11.3 ± 0.5 | 0* | 21.7 ± 2* |
| UAZ021 | RAEB-t | 3 | 3 | 0 | 20 ± 5.5 | 3 ± 2.6* | 28 ± 8 |
| UAZ022 | RAEB-t | 1 | 4 | 0 | 6 ± 2 | 1.7 ± 2* | 17 ± 11* |
| UAZ023 | RAEB-t | 3 | 2 | 0 | 103 ± 23 | 63 ± 25 | 158 ± 80 |
| UAZ024 | CMML | 0 | 0 | 0 | 238 ± 8.5 | 195 ± 7.7* | 247 ± 1.1 |
| UAZ025 | CMML | 3 | 1 | 0 | 65 ± 30 | 30 ± 7.5 | 128 ± 21* |
| UAZ026 | CMML | 3 | 0 | 0 | 53 ± 23 | 52 ± 5.9 | 83 ± 12* |
| UAZ027 | CMML | 4 | 1 | 0 | 234 ± 50 | 266 ± 17 | 281 ± 24 |
P < .05 versus controls.
ND, not done.