Effect of VEGF neutralization on TNF-α and IL-1β generation from MDS BM-MNC in 24-hour suspension culture
| UPN . | TNF-α (pg/mL) . | IL-1β (pg/mL) . | ||
|---|---|---|---|---|
| Control . | Anti-VEGF . | Control . | Anti-VEGF . | |
| UAZ006 | 1.096 ± 0.17 | 0.336 ± 0.0323-150 | < 0.125 | < 0.125 |
| UAZ009 | 9.534 ± 1.2 | 2.973 ± 0.213-150 | 5.217 ± 0.12 | 0.903 ± 0.193-150 |
| UAZ012 | 1.157 ± 0.9 | 0.518 ± 0.39 | 1.781 ± 0.20 | 0.748 ± 0.043-150 |
| UAZ015 | 37.79 ± 0.47 | 18.41 ± 1.493-150 | 8.796 ± 1.4 | 5.675 ± 0.173-150 |
| UAZ016 | 6.731 ± 1.45 | 6.813 ± 0.14 | 8.619 ± 0.41 | 5.418 ± 0.413-150 |
| UAZ017 | 3.46 ± 0.79 | 3.101 ± 0.11 | 0.912 ± 0.50 | 0.482 ± 0.33 |
| UAZ018 | 4.69 ± 0.26 | 4.91 ± 0.81 | 8.951 ± 0.24 | 6.980 ± 0.553-150 |
| UAZ019 | 3.083 ± 0.13 | 0.767 ± 0.183-150 | 0.905 ± 0.09 | 0.02 ± 0.013-150 |
| UAZ020 | 4.933 ± 1.49 | 2.003 ± 0.193-150 | 4.394 ± 0.18 | 1.754 ± 0.053-150 |
| UAZ021 | 3.683 ± 0.13 | 1.897 ± 1.03-150 | 1.92 ± 0.03 | 0.091 ± 0.063-150 |
| UAZ022 | 9.699 ± 2.92 | 5.030 ± 0.483-150 | 7.272 ± 1.08 | 7.360 ± 0.12 |
| UAZ023 | 5.492 ± 0.55 | 3.034 ± 0.023-150 | 3.497 ± 0.29 | 3.204 ± 0.11 |
| UAZ024 | 3.937 ± 0.02 | 2.94 ± 0.463-150 | 4.568 ± 0.07 | 3.27 ± 0.713-150 |
| UAZ025 | 17.925 ± 8.94 | 20.422 ± 0.62 | 13.126 ± 0.40 | 13.314 ± 0.18 |
| UAZ028 | 11.617 ± 1.37 | 12.321 ± 0.64 | 6.93 ± 0.99 | 4.79 ± 0.44 |
| UAZ029 | 59.039 ± 2.03 | 53.834 ± 1.85 | 8.355 ± 0.41 | 7.656 ± 0.30 |
| UAZ030 | 53.543 ± 1.23 | 51.607 ± 0.98 | 8.089 ± 0.14 | 7.791 ± 0.55 |
| UAZ031 | 66.66 ± 1.10 | 15.791 ± 0.393-150 | 8.012 ± 0.31 | 7.778 ± 0.41 |
| UAZ032 | 50.435 ± 5.61 | 49.471 ± 0.56 | 8.037 ± 0.27 | 7.755 ± 0.49 |
| UPN . | TNF-α (pg/mL) . | IL-1β (pg/mL) . | ||
|---|---|---|---|---|
| Control . | Anti-VEGF . | Control . | Anti-VEGF . | |
| UAZ006 | 1.096 ± 0.17 | 0.336 ± 0.0323-150 | < 0.125 | < 0.125 |
| UAZ009 | 9.534 ± 1.2 | 2.973 ± 0.213-150 | 5.217 ± 0.12 | 0.903 ± 0.193-150 |
| UAZ012 | 1.157 ± 0.9 | 0.518 ± 0.39 | 1.781 ± 0.20 | 0.748 ± 0.043-150 |
| UAZ015 | 37.79 ± 0.47 | 18.41 ± 1.493-150 | 8.796 ± 1.4 | 5.675 ± 0.173-150 |
| UAZ016 | 6.731 ± 1.45 | 6.813 ± 0.14 | 8.619 ± 0.41 | 5.418 ± 0.413-150 |
| UAZ017 | 3.46 ± 0.79 | 3.101 ± 0.11 | 0.912 ± 0.50 | 0.482 ± 0.33 |
| UAZ018 | 4.69 ± 0.26 | 4.91 ± 0.81 | 8.951 ± 0.24 | 6.980 ± 0.553-150 |
| UAZ019 | 3.083 ± 0.13 | 0.767 ± 0.183-150 | 0.905 ± 0.09 | 0.02 ± 0.013-150 |
| UAZ020 | 4.933 ± 1.49 | 2.003 ± 0.193-150 | 4.394 ± 0.18 | 1.754 ± 0.053-150 |
| UAZ021 | 3.683 ± 0.13 | 1.897 ± 1.03-150 | 1.92 ± 0.03 | 0.091 ± 0.063-150 |
| UAZ022 | 9.699 ± 2.92 | 5.030 ± 0.483-150 | 7.272 ± 1.08 | 7.360 ± 0.12 |
| UAZ023 | 5.492 ± 0.55 | 3.034 ± 0.023-150 | 3.497 ± 0.29 | 3.204 ± 0.11 |
| UAZ024 | 3.937 ± 0.02 | 2.94 ± 0.463-150 | 4.568 ± 0.07 | 3.27 ± 0.713-150 |
| UAZ025 | 17.925 ± 8.94 | 20.422 ± 0.62 | 13.126 ± 0.40 | 13.314 ± 0.18 |
| UAZ028 | 11.617 ± 1.37 | 12.321 ± 0.64 | 6.93 ± 0.99 | 4.79 ± 0.44 |
| UAZ029 | 59.039 ± 2.03 | 53.834 ± 1.85 | 8.355 ± 0.41 | 7.656 ± 0.30 |
| UAZ030 | 53.543 ± 1.23 | 51.607 ± 0.98 | 8.089 ± 0.14 | 7.791 ± 0.55 |
| UAZ031 | 66.66 ± 1.10 | 15.791 ± 0.393-150 | 8.012 ± 0.31 | 7.778 ± 0.41 |
| UAZ032 | 50.435 ± 5.61 | 49.471 ± 0.56 | 8.037 ± 0.27 | 7.755 ± 0.49 |
P < .05 versus controls.