Gene expression data from cDNA arrays
| . | Gene . | AML specimens . | Normal specimens . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 1 . | 2 . | 3 . | ||
| CD34 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 1 | DAPK | 1 | 4 | 4 | 4 | 2 | 2 | 2 | 0 | 0 | 0 |
| 2 | IRF-1 | 1 | 4 | 4 | 4 | 2 | 1 | 2 | 0 | 0 | 0 |
| 3 | AML-1 | 1 | 0 | 0 | 1 | 1 | 1 | — | 0 | 0 | 0 |
| 4 | AF-4 | 1 | 0.5 | 1 | 2 | 1 | 0 | — | 0 | 0 | — |
| 5 | EWS | 1 | 2 | 2 | 2 | 2 | 1 | — | 0 | 0 | — |
| 6 | Ikaros | 4 | 0 | 0 | 4 | 2 | 4 | — | 1 | 1 | 0 |
| 7 | STAT6 | 2 | 2 | 1 | 2 | 2 | 0 | — | 1 | 0 | — |
| . | Gene . | AML specimens . | Normal specimens . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 1 . | 2 . | 3 . | ||
| CD34 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 1 | DAPK | 1 | 4 | 4 | 4 | 2 | 2 | 2 | 0 | 0 | 0 |
| 2 | IRF-1 | 1 | 4 | 4 | 4 | 2 | 1 | 2 | 0 | 0 | 0 |
| 3 | AML-1 | 1 | 0 | 0 | 1 | 1 | 1 | — | 0 | 0 | 0 |
| 4 | AF-4 | 1 | 0.5 | 1 | 2 | 1 | 0 | — | 0 | 0 | — |
| 5 | EWS | 1 | 2 | 2 | 2 | 2 | 1 | — | 0 | 0 | — |
| 6 | Ikaros | 4 | 0 | 0 | 4 | 2 | 4 | — | 1 | 1 | 0 |
| 7 | STAT6 | 2 | 2 | 1 | 2 | 2 | 0 | — | 1 | 0 | — |
Table numbers reflect relative expression levels in comparison to CD34. AML specimens correspond to the following: 1 = French-American-British (FAB) M4, hyperdiploid (white blood count [WBC] = 80 K, 99% CD123+); 2 = FAB M2, normal karyotype (WBC = >200 K, 99% CD123+); 3 = FAB M1, karyotype not determined (WBC = 130 K, 100% CD123+); 4 = FAB M2/M6, monosomy 7 (WBC = 86 K, 95% CD123+); 5 = FAB M4, normal karyotype (WBC = >100 K, 99% CD123+); 6 = FAB M1, normal karyotype (WBC = 140 K, 97% CD123+); 7 = FAB M4, normal karyotype (WBC = >100 K, 98% CD123+). All samples were derived from sorted CD34+/CD38− cells. Bone marrow specimens were derived from normal donors.
AML indicates acute myelogenous leukemia; DAPK, death-associated protein kinase; and IRF, interferon regulatory factor.