Table 1. The IC 80 values of the Ph... | American Society of Hematology

Table 1.

The IC₈₀ values of the Ph⁺leukemia cell lines for ST1571 and combined agents^*,^†

Drug	KU812	K562	TCC-S	TCC-Y
ST1571 (nM)	84 ± 9	247 ± 30	72 ± 6	510 ± 80
Recombinant IFN-α (IU/mL)	4400 ± 500	> 10 000	1500 ± 300^‡	4500 ± 600
Natural IFN-α (IU/mL)	2400 ± 400	> 10 000	1100 ± 200^‡	2800 ± 450
Hydroxyurea (mM)	0.75 ± 0.04	1.1 ± 0.2	0.17 ± 0.02	0.52 ± 0.04
Cytarabine (nM)	8.9 ± 1.1	92 ± 17	410 ± 56	5.1 ± 0.6
Homoharringtonine (nM)	56 ± 3	92 ± 11	57 ± 6	80 ± 8
Doxorubicin (nM)	27 ± 3	70 ± 6	39 ± 6	82 ± 11
Etoposide (μM)	2.0 ± 0.2	4.2 ± 0.6	2.6 ± 0.4	2.1 ± 0.2
Hydroperoxy-cyclophosphamide (μM)	4.8 ± 0.6	8.1 ± 0.6	5.3 ± 0.7	3 ± 0.5
Methotrexate (nM)	14 ± 1	86 ± 7	52 ± 7	64 ± 9
Vincristine (nM)	0.88 ± 0.03	7.1 ± 0.9	0.75 ± 0.03	0.66 ± 0.02

Drug	KU812	K562	TCC-S	TCC-Y
ST1571 (nM)	84 ± 9	247 ± 30	72 ± 6	510 ± 80
Recombinant IFN-α (IU/mL)	4400 ± 500	> 10 000	1500 ± 300^‡	4500 ± 600
Natural IFN-α (IU/mL)	2400 ± 400	> 10 000	1100 ± 200^‡	2800 ± 450
Hydroxyurea (mM)	0.75 ± 0.04	1.1 ± 0.2	0.17 ± 0.02	0.52 ± 0.04
Cytarabine (nM)	8.9 ± 1.1	92 ± 17	410 ± 56	5.1 ± 0.6
Homoharringtonine (nM)	56 ± 3	92 ± 11	57 ± 6	80 ± 8
Doxorubicin (nM)	27 ± 3	70 ± 6	39 ± 6	82 ± 11
Etoposide (μM)	2.0 ± 0.2	4.2 ± 0.6	2.6 ± 0.4	2.1 ± 0.2
Hydroperoxy-cyclophosphamide (μM)	4.8 ± 0.6	8.1 ± 0.6	5.3 ± 0.7	3 ± 0.5
Methotrexate (nM)	14 ± 1	86 ± 7	52 ± 7	64 ± 9
Vincristine (nM)	0.88 ± 0.03	7.1 ± 0.9	0.75 ± 0.03	0.66 ± 0.02

KU812, K562, and TCC-S were exposed to the drugs for 5 days and TCC-Y for 7 days.

Values represent the mean ± SEM of at least 3 independent experiments.

IC₄₀.