Inhibition of clonal proliferation of cancer cell lines by vitamin D3 analogs
| Cell lines . | Inhibition of clonal proliferation, ED50 (M) . | ||||
|---|---|---|---|---|---|
| 1,25(OH)2D3 . | Gemini-19-nor . | Gemini-3-epi . | Gemini-5,6-trans . | Gemini-1-F-25-OH . | |
| HL-60 | 1.2 × 10−8 | 1.7 × 10−10 | 2.8 × 10−8 | 1.2 × 10−8 | 4.3 × 10−9 |
| NB4 | 2.6 × 10−8 | 6.4 × 10−13 | 3.9 × 10−8 | 2.1 × 10−8 | 4.0 × 10−9 |
| MCF-7 | 3.7 × 10−8 | 1.6 × 10−9 | 1.6 × 10−7 | 1.2 × 10−7 | 4.1 × 10−8 |
| LNCaP | × 10−7 | 1.7 × 10−9 | 5.0 × 10−8 | 7.0 × 10−8 | 1.0 × 10−7 |
| Cell lines . | Inhibition of clonal proliferation, ED50 (M) . | ||||
|---|---|---|---|---|---|
| 1,25(OH)2D3 . | Gemini-19-nor . | Gemini-3-epi . | Gemini-5,6-trans . | Gemini-1-F-25-OH . | |
| HL-60 | 1.2 × 10−8 | 1.7 × 10−10 | 2.8 × 10−8 | 1.2 × 10−8 | 4.3 × 10−9 |
| NB4 | 2.6 × 10−8 | 6.4 × 10−13 | 3.9 × 10−8 | 2.1 × 10−8 | 4.0 × 10−9 |
| MCF-7 | 3.7 × 10−8 | 1.6 × 10−9 | 1.6 × 10−7 | 1.2 × 10−7 | 4.1 × 10−8 |
| LNCaP | × 10−7 | 1.7 × 10−9 | 5.0 × 10−8 | 7.0 × 10−8 | 1.0 × 10−7 |
Results derived from Figure 2; the concentration of vitamin D3 compound that induced 50% clonal inhibition (ED50). HL-60, human myeloblastic leukemia cells; NB4, human acute promyelocytic cells; MCF-7, estrogen-receptor positive breast cancer cells; LNCaP, androgen receptor-positive prostate cancer cells.